Details
- scope
- vip-interneurons
- section_id
- section_08
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json
- effect_size
- 10–20% of postsynaptic neurons co-received both ACh and GABA from ChAT-VIP cells; ChAT-VIP silencing impaired attention performance.
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-08-in-vivo-behavior
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC).
- section_title
- In Vivo Function During Behavior
- evidence_summary
- Optogenetic stimulation in ChAT-Cre × VIP-Cre mice + paired recordings + behavior (5-CSRTT attention task).
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- supported
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-08-in-vivo-behavior
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_08_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
A ~0.5–1% subpopulation of cortical VIP interneurons co-expresses choline acetyltransferase (ChAT-VIP) and locally releases acetylcholine that directly excites neighboring pyramidal and inhibitory neurons via fast cholinergic synaptic transmission, controlling attention behavior independently of basal-forebrain ACh.
- raw_fields
{ "n": null, "doi": "10.1038/s41467-019-13244-9", "year": "2019", "claim": "A ~0.5–1% subpopulation of cortical VIP interneurons co-expresses choline acetyltransferase (ChAT-VIP) and locally releases acetylcholine that directly excites neighboring pyramidal and inhibitory neurons via fast cholinergic synaptic transmission, controlling attention behavior independently of basal-forebrain ACh.", "title": "Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention", "journal": "", "species": "mouse", "cite_key": "Obermayer2019", "evidence": "Optogenetic stimulation in ChAT-Cre × VIP-Cre mice + paired recordings + behavior (5-CSRTT attention task).", "effect_size": "10–20% of postsynaptic neurons co-received both ACh and GABA from ChAT-VIP cells; ChAT-VIP silencing impaired attention performance.", "text_access": "fulltext", "_source_cluster": "cluster_13_neuromodulation", "replication_status": "supported", "_source_cluster_index": 12, "claim_source_sentence": "ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC).", "replication_evidence_dois": [ "10.7554/elife.57749", "10.1371/journal.pbio.3000613" ], "effect_size_source_sentence": "A fraction (10–20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons." }- source_refs
[ "paper:paper-d66bdd18df1c" ]
- evidence_refs
[ { "ref": "paper:paper-d66bdd18df1c" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }