Version history

{
  "scope": "mouse V1, in vitro slice with optogenetics + paired recordings",
  "claim_text": "In mouse visual cortex L2/3 and L5, VIP interneurons preferentially target somatostatin (Sst) interneurons; inhibition from VIP onto Sst cells is far larger than onto pyramidal neurons (~7×), establishing the canonical VIP→Sst disinhibitory motif.",
  "raw_fields": {
    "n": 11,
    "doi": "10.1038/nn.3446",
    "claim": "In mouse visual cortex L2/3 and L5, VIP interneurons preferentially target somatostatin (Sst) interneurons; inhibition from VIP onto Sst cells is far larger than onto pyramidal neurons (~7×), establishing the canonical VIP→Sst disinhibitory motif.",
    "title": null,
    "cite_key": "Pfeffer2013",
    "evidence": "Optogenetic activation of VIP-Cre-ChR2 cells with paired recordings of Sst vs pyramid postsynaptic targets in mouse V1.",
    "effect_size": "IPSQ Sst 4.6±1.5 pC vs IPSQ Pyr 0.6±0.2 pC; INC VIP→Sst = 0.42±0.14 pC vs INC VIP→pyramid = 0.06±0.02 pC",
    "text_access": "fulltext",
    "study_system": "mouse V1, in vitro slice with optogenetics + paired recordings",
    "_source_cluster": "cluster_05_synaptic_connectivity",
    "replication_status": "independently_replicated",
    "_source_cluster_index": 0,
    "claim_source_sentence": "Inhibition mediated by VIP cells onto Sst-expressing cells was much larger than onto the simultaneously recorded pyramids, (average IPSQ Sst 4.6±1.5pC; average IPSQ Pyr 0.6±0.2pC; n=11; INC VIP→Sst =0.42±0.14pC as compared to the much smaller INC VIP→pyramid =0.06±0.02pC and ) and larger in L2/3 tha",
    "replication_evidence_dois": [
      "10.1038/nature12676",
      "10.1038/nn.3544",
      "10.1523/jneurosci.3646-15.2016"
    ],
    "effect_size_source_sentence": "Inhibition mediated by VIP cells onto Sst-expressing cells was much larger than onto the simultaneously recorded pyramids, (average IPSQ Sst 4.6±1.5pC; average IPSQ Pyr 0.6±0.2pC; n=11; INC VIP→Sst =0.42±0.14pC as compared to the much smaller INC VIP→pyramid =0.06±0.02pC"
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "effect_size": "IPSQ Sst 4.6±1.5 pC vs IPSQ Pyr 0.6±0.2 pC; INC VIP→Sst = 0.42±0.14 pC vs INC VIP→pyramid = 0.06±0.02 pC",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-1659c2dc5d60"
  ],
  "source_span": "Inhibition mediated by VIP cells onto Sst-expressing cells was much larger than onto the simultaneously recorded pyramids, (average IPSQ Sst 4.6±1.5pC; average IPSQ Pyr 0.6±0.2pC; n=11; INC VIP→Sst =0.42±0.14pC as compared to the much smaller INC VIP→pyramid =0.06±0.02pC and ) and larger in L2/3 tha",
  "study_system": "mouse V1, in vitro slice with optogenetics + paired recordings",
  "evidence_refs": [
    {
      "ref": "paper:paper-1659c2dc5d60"
    }
  ],
  "section_title": "Synaptic Properties and Connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Optogenetic activation of VIP-Cre-ChR2 cells with paired recordings of Sst vs pyramid postsynaptic targets in mouse V1.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-06-synaptic-properties",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_06_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}