- claim_text
In mouse visual cortex L2/3 and L5, VIP interneurons preferentially target somatostatin (Sst) interneurons; inhibition from VIP onto Sst cells is far larger than onto pyramidal neurons (~7×), establishing the canonical VIP→Sst disinhibitory motif.
- raw_fields
{
"n": 11,
"doi": "10.1038/nn.3446",
"claim": "In mouse visual cortex L2/3 and L5, VIP interneurons preferentially target somatostatin (Sst) interneurons; inhibition from VIP onto Sst cells is far larger than onto pyramidal neurons (~7×), establishing the canonical VIP→Sst disinhibitory motif.",
"title": null,
"cite_key": "Pfeffer2013",
"evidence": "Optogenetic activation of VIP-Cre-ChR2 cells with paired recordings of Sst vs pyramid postsynaptic targets in mouse V1.",
"effect_size": "IPSQ Sst 4.6±1.5 pC vs IPSQ Pyr 0.6±0.2 pC; INC VIP→Sst = 0.42±0.14 pC vs INC VIP→pyramid = 0.06±0.02 pC",
"text_access": "fulltext",
"study_system": "mouse V1, in vitro slice with optogenetics + paired recordings",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "independently_replicated",
"_source_cluster_index": 0,
"claim_source_sentence": "Inhibition mediated by VIP cells onto Sst-expressing cells was much larger than onto the simultaneously recorded pyramids, (average IPSQ Sst 4.6±1.5pC; average IPSQ Pyr 0.6±0.2pC; n=11; INC VIP→Sst =0.42±0.14pC as compared to the much smaller INC VIP→pyramid =0.06±0.02pC and ) and larger in L2/3 tha",
"replication_evidence_dois": [
"10.1038/nature12676",
"10.1038/nn.3544",
"10.1523/jneurosci.3646-15.2016"
],
"effect_size_source_sentence": "Inhibition mediated by VIP cells onto Sst-expressing cells was much larger than onto the simultaneously recorded pyramids, (average IPSQ Sst 4.6±1.5pC; average IPSQ Pyr 0.6±0.2pC; n=11; INC VIP→Sst =0.42±0.14pC as compared to the much smaller INC VIP→pyramid =0.06±0.02pC"
}- source_refs
[
"paper:paper-1659c2dc5d60"
]
- source_span
Inhibition mediated by VIP cells onto Sst-expressing cells was much larger than onto the simultaneously recorded pyramids, (average IPSQ Sst 4.6±1.5pC; average IPSQ Pyr 0.6±0.2pC; n=11; INC VIP→Sst =0.42±0.14pC as compared to the much smaller INC VIP→pyramid =0.06±0.02pC and ) and larger in L2/3 tha
- evidence_refs
[
{
"ref": "paper:paper-1659c2dc5d60"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}