Details
- scope
- hAPP transgenic mice and human AD postmortem tissue
- claim_text
- hAPP transgenic mice and AD patients have decreased Nav1.1 levels; restoring Nav1.1 increases inhibitory synaptic activity, gamma oscillations, and reduces memory deficits
- section_id
- section_11_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
- effect_size
- Restoring Nav1.1 levels increased inhibitory synaptic activity and gamma oscillations and reduced hypersynchrony, memory deficits, and premature mortality
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-11
- source_kind
- review_finding
- source_path
- evidence/section_11_evidence_package.json
- source_span
- hAPP mice and AD patients had decreased levels of the interneuron-specific and PV cell-predominant voltage-gated sodium channel subunit Nav1.1.
- study_system
- hAPP transgenic mice and human AD postmortem tissue
- section_title
- Species Translation, Human Data, and Disease Models
- evidence_summary
- Landmark study linking PV cell Nav1.1 loss to network dysfunction in AD model
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-11
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.cell.2012.02.046", "claim": "hAPP transgenic mice and AD patients have decreased Nav1.1 levels; restoring Nav1.1 increases inhibitory synaptic activity, gamma oscillations, and reduces memory deficits", "evidence": "Landmark study linking PV cell Nav1.1 loss to network dysfunction in AD model", "effect_size": "Restoring Nav1.1 levels increased inhibitory synaptic activity and gamma oscillations and reduced hypersynchrony, memory deficits, and premature mortality", "text_access": "fulltext", "study_system": "hAPP transgenic mice and human AD postmortem tissue", "replication_status": "independently_replicated", "claim_source_sentence": "hAPP mice and AD patients had decreased levels of the interneuron-specific and PV cell-predominant voltage-gated sodium channel subunit Nav1.1.", "replication_evidence_dois": [ "10.1523/jneurosci.5270-06.2007" ], "effect_size_source_sentence": "Restoring Nav1.1 levels in hAPP mice by Nav1.1-BAC expression increased inhibitory synaptic activity and gamma oscillations and reduced hypersynchrony, memory deficits, and premature mortality." }- source_refs
[ "paper:paper-4cb1cf98f0c1" ]
- evidence_refs
[ { "ref": "paper:paper-4cb1cf98f0c1" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }