Version history

{
  "scope": "hAPP transgenic mice and human AD postmortem tissue",
  "claim_text": "hAPP transgenic mice and AD patients have decreased Nav1.1 levels; restoring Nav1.1 increases inhibitory synaptic activity, gamma oscillations, and reduces memory deficits",
  "raw_fields": {
    "n": 0,
    "doi": "10.1016/j.cell.2012.02.046",
    "claim": "hAPP transgenic mice and AD patients have decreased Nav1.1 levels; restoring Nav1.1 increases inhibitory synaptic activity, gamma oscillations, and reduces memory deficits",
    "evidence": "Landmark study linking PV cell Nav1.1 loss to network dysfunction in AD model",
    "effect_size": "Restoring Nav1.1 levels increased inhibitory synaptic activity and gamma oscillations and reduced hypersynchrony, memory deficits, and premature mortality",
    "text_access": "fulltext",
    "study_system": "hAPP transgenic mice and human AD postmortem tissue",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "hAPP mice and AD patients had decreased levels of the interneuron-specific and PV cell-predominant voltage-gated sodium channel subunit Nav1.1.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.5270-06.2007"
    ],
    "effect_size_source_sentence": "Restoring Nav1.1 levels in hAPP mice by Nav1.1-BAC expression increased inhibitory synaptic activity and gamma oscillations and reduced hypersynchrony, memory deficits, and premature mortality."
  },
  "section_id": "section_11_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "effect_size": "Restoring Nav1.1 levels increased inhibitory synaptic activity and gamma oscillations and reduced hypersynchrony, memory deficits, and premature mortality",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-4cb1cf98f0c1"
  ],
  "source_span": "hAPP mice and AD patients had decreased levels of the interneuron-specific and PV cell-predominant voltage-gated sodium channel subunit Nav1.1.",
  "study_system": "hAPP transgenic mice and human AD postmortem tissue",
  "evidence_refs": [
    {
      "ref": "paper:paper-4cb1cf98f0c1"
    }
  ],
  "section_title": "Species Translation, Human Data, and Disease Models",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Landmark study linking PV cell Nav1.1 loss to network dysfunction in AD model",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}