Version history

{
  "scope": "mouse, D1-Cre line",
  "claim_text": "Cell-type-targeted CRISPR-activation of Drd1 in striatal D1-MSNs disrupts baseline striatal physiology and produces behavioral deficits.",
  "raw_fields": {
    "n": 3,
    "doi": "10.1523/eneuro.0157-25.2025",
    "claim": "Cell-type-targeted CRISPR-activation of Drd1 in striatal D1-MSNs disrupts baseline striatal physiology and produces behavioral deficits.",
    "cite_key": "Campbell2025",
    "evidence": "D1-Cre x dCas9-VPR mice with Drd1-targeting sgRNAs; ex vivo recordings and behavioral assays.",
    "effect_size": "1 and",
    "text_access": "fulltext",
    "study_system": "mouse, D1-Cre line",
    "source_cluster_id": "cluster_10",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "The two main cell types in the striatum, dopamine receptor 1 and adenosine receptor 2a spiny projection neurons (D1-SPNs and A2A-SPNs), have distinct roles in regulating motor- and reward-related behaviors.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "The two main cell types in the striatum, dopamine receptor 1 and adenosine receptor 2a spiny projection neurons (D1-SPNs and A2A-SPNs), have distinct roles in regulating motor- and reward-related behaviors."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": "1 and",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-07ecf011e408"
  ],
  "source_span": "The two main cell types in the striatum, dopamine receptor 1 and adenosine receptor 2a spiny projection neurons (D1-SPNs and A2A-SPNs), have distinct roles in regulating motor- and reward-related behaviors.",
  "study_system": "mouse, D1-Cre line",
  "evidence_refs": [
    {
      "ref": "paper:paper-07ecf011e408"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "D1-Cre x dCas9-VPR mice with Drd1-targeting sgRNAs; ex vivo recordings and behavioral assays.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}