Details
- scope
- mouse, D1-Cre line
- claim_text
- Cell-type-targeted CRISPR-activation of Drd1 in striatal D1-MSNs disrupts baseline striatal physiology and produces behavioral deficits.
- section_id
- section_11
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- effect_size
- 1 and
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-11
- source_kind
- review_finding
- source_path
- evidence/section_11_evidence_package.json
- source_span
- The two main cell types in the striatum, dopamine receptor 1 and adenosine receptor 2a spiny projection neurons (D1-SPNs and A2A-SPNs), have distinct roles in regulating motor- and reward-related behaviors.
- study_system
- mouse, D1-Cre line
- section_title
- Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)
- evidence_summary
- D1-Cre x dCas9-VPR mice with Drd1-targeting sgRNAs; ex vivo recordings and behavioral assays.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-11
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 3, "doi": "10.1523/eneuro.0157-25.2025", "claim": "Cell-type-targeted CRISPR-activation of Drd1 in striatal D1-MSNs disrupts baseline striatal physiology and produces behavioral deficits.", "cite_key": "Campbell2025", "evidence": "D1-Cre x dCas9-VPR mice with Drd1-targeting sgRNAs; ex vivo recordings and behavioral assays.", "effect_size": "1 and", "text_access": "fulltext", "study_system": "mouse, D1-Cre line", "source_cluster_id": "cluster_10", "replication_status": "replication_unknown", "claim_source_sentence": "The two main cell types in the striatum, dopamine receptor 1 and adenosine receptor 2a spiny projection neurons (D1-SPNs and A2A-SPNs), have distinct roles in regulating motor- and reward-related behaviors.", "replication_evidence_dois": [], "effect_size_source_sentence": "The two main cell types in the striatum, dopamine receptor 1 and adenosine receptor 2a spiny projection neurons (D1-SPNs and A2A-SPNs), have distinct roles in regulating motor- and reward-related behaviors." }- source_refs
[ "paper:paper-07ecf011e408" ]
- evidence_refs
[ { "ref": "paper:paper-07ecf011e408" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }