Version history

{
  "scope": "mouse hippocampal slices (DG, CA3, CA1), in vitro paired recordings + computational model",
  "claim_text": "Unitary IPSCs at basket cell-to-basket cell synapses have faster decay than at BC-to-principal cell synapses (target cell-specific kinetics), and electrical coupling was found in a subset of BC-BC pairs. Combined with fast inhibition and network structure, these enable gamma oscillations at 20-110 Hz with high coherence",
  "raw_fields": {
    "n": 0,
    "doi": "10.1073/pnas.192233099",
    "claim": "Unitary IPSCs at basket cell-to-basket cell synapses have faster decay than at BC-to-principal cell synapses (target cell-specific kinetics), and electrical coupling was found in a subset of BC-BC pairs. Combined with fast inhibition and network structure, these enable gamma oscillations at 20-110 Hz with high coherence",
    "evidence": "Paired recordings from PV basket cells in hippocampal subfields using PV-EGFP transgenic mice, plus computational interneuron network model",
    "effect_size": "IPSC decay time constants: 2.5 ms (DG), 1.2 ms (CA3), 1.8 ms (CA1) at 33-34°C; gamma range 20-110 Hz",
    "text_access": "fulltext",
    "study_system": "mouse hippocampal slices (DG, CA3, CA1), in vitro paired recordings + computational model",
    "replication_status": "independently replicated",
    "claim_source_sentence": "The decay of unitary IPSCs at BC-BC synapses was significantly faster than that at BC-principal cell synapses, indicating target cell-specific differences in IPSC kinetics. In addition, electrical coupling was found in a subset of BC-BC pairs.",
    "replication_evidence_dois": [
      "10.1146/annurev-neuro-062111-150444"
    ],
    "effect_size_source_sentence": "Unitary inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8 ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively (33-34°C)."
  },
  "section_id": "section_07_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "effect_size": "IPSC decay time constants: 2.5 ms (DG), 1.2 ms (CA3), 1.8 ms (CA1) at 33-34°C; gamma range 20-110 Hz",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-07",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-a9bffd9b9fbb"
  ],
  "source_span": "The decay of unitary IPSCs at BC-BC synapses was significantly faster than that at BC-principal cell synapses, indicating target cell-specific differences in IPSC kinetics. In addition, electrical coupling was found in a subset of BC-BC pairs.",
  "study_system": "mouse hippocampal slices (DG, CA3, CA1), in vitro paired recordings + computational model",
  "evidence_refs": [
    {
      "ref": "paper:paper-a9bffd9b9fbb"
    }
  ],
  "section_title": "Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "Paired recordings from PV basket cells in hippocampal subfields using PV-EGFP transgenic mice, plus computational interneuron network model",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-07",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}