Unitary IPSCs at basket cell-to-basket cell synapses have faster decay than at…

Unitary IPSCs at basket cell-to-basket cell synapses have faster decay than at BC-to-principal cell synapses (target cell-specific kinetics), and electrical coupling was found in a subset of BC-BC pairs. Combined with fast inhibition and network structure, these enable gamma oscillations at 20-110 Hz with high coherence

{
  "n": 0,
  "doi": "10.1073/pnas.192233099",
  "claim": "Unitary IPSCs at basket cell-to-basket cell synapses have faster decay than at BC-to-principal cell synapses (target cell-specific kinetics), and electrical coupling was found in a subset of BC-BC pairs. Combined with fast inhibition and network structure, these enable gamma oscillations at 20-110 Hz with high coherence",
  "evidence": "Paired recordings from PV basket cells in hippocampal subfields using PV-EGFP transgenic mice, plus computational interneuron network model",
  "effect_size": "IPSC decay time constants: 2.5 ms (DG), 1.2 ms (CA3), 1.8 ms (CA1) at 33-34°C; gamma range 20-110 Hz",
  "text_access": "fulltext",
  "study_system": "mouse hippocampal slices (DG, CA3, CA1), in vitro paired recordings + computational model",
  "replication_status": "independently replicated",
  "claim_source_sentence": "The decay of unitary IPSCs at BC-BC synapses was significantly faster than that at BC-principal cell synapses, indicating target cell-specific differences in IPSC kinetics. In addition, electrical coupling was found in a subset of BC-BC pairs.",
  "replication_evidence_dois": [
    "10.1146/annurev-neuro-062111-150444"
  ],
  "effect_size_source_sentence": "Unitary inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8 ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively (33-34°C)."
}

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  "paper:paper-a9bffd9b9fbb"
]

The decay of unitary IPSCs at BC-BC synapses was significantly faster than that at BC-principal cell synapses, indicating target cell-specific differences in IPSC kinetics. In addition, electrical coupling was found in a subset of BC-BC pairs.

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