Version history

{
  "scope": "6-OHDA-lesioned mice, optogenetic cell-type-specific GPe stimulation, electrophysiology and behavior",
  "claim_text": "Cell-type-specific stimulation that elevates PV+ GPe neuron activity relative to Lhx6+ neurons in dopamine-depleted mice produces long-lasting motor recovery — hours beyond stimulation — implicating the GPe-cell-type balance as a therapeutic target.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nn.4559",
    "claim": "Cell-type-specific stimulation that elevates PV+ GPe neuron activity relative to Lhx6+ neurons in dopamine-depleted mice produces long-lasting motor recovery — hours beyond stimulation — implicating the GPe-cell-type balance as a therapeutic target.",
    "cite_key": "Mastro2017",
    "evidence": "",
    "effect_size": "restored movement; attenuated pathological output for hours beyond stimulation",
    "text_access": "fulltext",
    "study_system": "6-OHDA-lesioned mice, optogenetic cell-type-specific GPe stimulation, electrophysiology and behavior",
    "source_cluster_id": "cluster_04",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "Within the prototypical population, neurons can be further subidivded based on expression of parvalbumin (PV-GPe) and lim homeobox 6 (Lhx6-GPe) 2 , 12 .",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Here we demonstrate that optogenetic interventions that dissociate the activity of two neuronal populations in the GPe, elevating the activity of parvalbumin (PV)-expressing GPe neurons over that of Lim homeobox 6 (Lhx6)-expressing GPe neurons, restores movement in dopamine-depleted mice and attenuates pathological activity of basal ganglia output neurons for hours beyond stimulation."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json",
  "effect_size": "restored movement; attenuated pathological output for hours beyond stimulation",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-057c9e8a8dad"
  ],
  "source_span": "Within the prototypical population, neurons can be further subidivded based on expression of parvalbumin (PV-GPe) and lim homeobox 6 (Lhx6-GPe) 2 , 12 .",
  "study_system": "6-OHDA-lesioned mice, optogenetic cell-type-specific GPe stimulation, electrophysiology and behavior",
  "evidence_refs": [
    {
      "ref": "paper:paper-057c9e8a8dad"
    }
  ],
  "section_title": "Pallidal Organization and the Disinhibition Principle",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}