Details
- scope
- 6-OHDA-lesioned mice, optogenetic cell-type-specific GPe stimulation, electrophysiology and behavior
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json
- effect_size
- restored movement; attenuated pathological output for hours beyond stimulation
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-05
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- Within the prototypical population, neurons can be further subidivded based on expression of parvalbumin (PV-GPe) and lim homeobox 6 (Lhx6-GPe) 2 , 12 .
- study_system
- 6-OHDA-lesioned mice, optogenetic cell-type-specific GPe stimulation, electrophysiology and behavior
- section_title
- Pallidal Organization and the Disinhibition Principle
- evidence_summary
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-05
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_05_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- claim_text
Cell-type-specific stimulation that elevates PV+ GPe neuron activity relative to Lhx6+ neurons in dopamine-depleted mice produces long-lasting motor recovery — hours beyond stimulation — implicating the GPe-cell-type balance as a therapeutic target.
- raw_fields
{ "n": 0, "doi": "10.1038/nn.4559", "claim": "Cell-type-specific stimulation that elevates PV+ GPe neuron activity relative to Lhx6+ neurons in dopamine-depleted mice produces long-lasting motor recovery — hours beyond stimulation — implicating the GPe-cell-type balance as a therapeutic target.", "cite_key": "Mastro2017", "evidence": "", "effect_size": "restored movement; attenuated pathological output for hours beyond stimulation", "text_access": "fulltext", "study_system": "6-OHDA-lesioned mice, optogenetic cell-type-specific GPe stimulation, electrophysiology and behavior", "source_cluster_id": "cluster_04", "replication_status": "replication_unknown", "claim_source_sentence": "Within the prototypical population, neurons can be further subidivded based on expression of parvalbumin (PV-GPe) and lim homeobox 6 (Lhx6-GPe) 2 , 12 .", "replication_evidence_dois": [], "effect_size_source_sentence": "Here we demonstrate that optogenetic interventions that dissociate the activity of two neuronal populations in the GPe, elevating the activity of parvalbumin (PV)-expressing GPe neurons over that of Lim homeobox 6 (Lhx6)-expressing GPe neurons, restores movement in dopamine-depleted mice and attenuates pathological activity of basal ganglia output neurons for hours beyond stimulation." }- source_refs
[ "paper:paper-057c9e8a8dad" ]
- evidence_refs
[ { "ref": "paper:paper-057c9e8a8dad" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }