The direct/indirect pathway dichotomy is conserved in the caudal striatum of mi…

{
  "n": null,
  "doi": "10.3389/fnana.2022.809446",
  "claim": "The direct/indirect pathway dichotomy is conserved in the caudal striatum of mice despite an uneven distribution of D1- and D2-SPNs in this region.",
  "cite_key": "Ogata2022",
  "evidence": "Cre-driver labeling and quantification of SPN subtypes across mouse caudal striatum.",
  "effect_size": "see source sentence",
  "text_access": "fulltext",
  "study_system": "mouse (Drd1/Drd2-Cre; quantitative anatomy)",
  "source_cluster_id": "cluster_02",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Axonal Projections From Caudo-Dorsal Striatum, Dopamine Receptor D1- or Dopamine Receptor D2-Poor Zones in Mouse So far, we have shown that the D1R-poor zone is composed of 79% of indirect pathway neurons expressing D2R, whereas the D2R-poor zone is composed of 82% of direct pathway neurons expressing D1R.",
  "replication_evidence_dois": [
    "10.1126/science.7256286",
    "10.1146/annurev.neuro.23.1.185"
  ],
  "effect_size_source_sentence": "For anterograde tracing, 10% biotinylated dextran amine (BDA 10kD) (D1956, Thermo Fisher Scientific, Inc., Waltham, MA, United States) in PBS, or 2.5% Phaseolus Vulgaris Leucoagglutinin (PHAL) (L-1110, Vector Laboratories, Burlingame, CA, United States) in 10 mM phosphate (pH 8.0) was injected in the cStr using a glass pipette (tip diameter, 15—25 μm)."
}

[
  "paper:paper-1c01b45481e1"
]

Axonal Projections From Caudo-Dorsal Striatum, Dopamine Receptor D1- or Dopamine Receptor D2-Poor Zones in Mouse So far, we have shown that the D1R-poor zone is composed of 79% of indirect pathway neurons expressing D2R, whereas the D2R-poor zone is composed of 82% of direct pathway neurons expressing D1R.

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