Version history

{
  "scope": "mouse (Drd1/Drd2-Cre; quantitative anatomy)",
  "claim_text": "The direct/indirect pathway dichotomy is conserved in the caudal striatum of mice despite an uneven distribution of D1- and D2-SPNs in this region.",
  "raw_fields": {
    "n": null,
    "doi": "10.3389/fnana.2022.809446",
    "claim": "The direct/indirect pathway dichotomy is conserved in the caudal striatum of mice despite an uneven distribution of D1- and D2-SPNs in this region.",
    "cite_key": "Ogata2022",
    "evidence": "Cre-driver labeling and quantification of SPN subtypes across mouse caudal striatum.",
    "effect_size": "see source sentence",
    "text_access": "fulltext",
    "study_system": "mouse (Drd1/Drd2-Cre; quantitative anatomy)",
    "source_cluster_id": "cluster_02",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "Axonal Projections From Caudo-Dorsal Striatum, Dopamine Receptor D1- or Dopamine Receptor D2-Poor Zones in Mouse So far, we have shown that the D1R-poor zone is composed of 79% of indirect pathway neurons expressing D2R, whereas the D2R-poor zone is composed of 82% of direct pathway neurons expressing D1R.",
    "replication_evidence_dois": [
      "10.1126/science.7256286",
      "10.1146/annurev.neuro.23.1.185"
    ],
    "effect_size_source_sentence": "For anterograde tracing, 10% biotinylated dextran amine (BDA 10kD) (D1956, Thermo Fisher Scientific, Inc., Waltham, MA, United States) in PBS, or 2.5% Phaseolus Vulgaris Leucoagglutinin (PHAL) (L-1110, Vector Laboratories, Burlingame, CA, United States) in 10 mM phosphate (pH 8.0) was injected in the cStr using a glass pipette (tip diameter, 15—25 μm)."
  },
  "section_id": "section_02",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "effect_size": "see source sentence",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-02",
  "source_kind": "review_finding",
  "source_path": "evidence/section_02_evidence_package.json",
  "source_refs": [
    "paper:paper-1c01b45481e1"
  ],
  "source_span": "Axonal Projections From Caudo-Dorsal Striatum, Dopamine Receptor D1- or Dopamine Receptor D2-Poor Zones in Mouse So far, we have shown that the D1R-poor zone is composed of 79% of indirect pathway neurons expressing D2R, whereas the D2R-poor zone is composed of 82% of direct pathway neurons expressing D1R.",
  "study_system": "mouse (Drd1/Drd2-Cre; quantitative anatomy)",
  "evidence_refs": [
    {
      "ref": "paper:paper-1c01b45481e1"
    }
  ],
  "section_title": "Classical Anatomy of the Triple Descending Projection",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Cre-driver labeling and quantification of SPN subtypes across mouse caudal striatum.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-02",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_02_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}