Here we directly relate patterns of excitatory synaptic connectivity to visual…

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scope: mouse; visual cortex; two-photon imaging, whole-cell patch, in vivo; Nature
claim_text: Here we directly relate patterns of excitatory synaptic connectivity to visual response properties of neighbouring layer 2/3 pyramidal neurons in mouse visual cortex at different postnatal age…
section_id: section_09
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-09-amplification-isn
source_kind: review_finding
source_path: evidence/section_09_evidence_package.json
study_system: mouse; visual cortex; two-photon imaging, whole-cell patch, in vivo; Nature
section_title: 9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: single_study
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-09-amplification-isn
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (7)

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  "claim": "Here we directly relate patterns of excitatory synaptic connectivity to visual response properties of neighbouring layer&#x2009;2/3 pyramidal neurons in mouse visual cortex at different postnatal age…",
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  "evidence": "Sensory processing occurs in neocortical microcircuits in which synaptic connectivity is highly structured and excitatory neurons form subnetworks that process related sensory information. However, the developmental mechanisms underlying the formation of functionally organized connectivity in cortical microcircuits remain unknown. Here we directly relate patterns of excitatory synaptic connectivity to visual response properties of neighbouring layer&#x2009;2/3 pyramidal neurons in mouse visual c...",
  "effect_size": "We next tested for developmental changes in recurrent connectivity between neurons not reliably responsive to visual stimuli, which were encountered at similar proportions at both age groups (fraction of non-significantly responsive neurons to repeated presentations of the natural movie: P13 – 15, 39%, 4133/10509 neurons; P22 – 26, 44%, 4691/10662).",
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effect_size

We next tested for developmental changes in recurrent connectivity between neurons not reliably responsive to visual stimuli, which were encountered at similar proportions at both age groups (fraction of non-significantly responsive neurons to repeated presentations of the natural movie: P13 – 15, 39%, 4133/10509 neurons; P22 – 26, 44%, 4691/10662).

source_refs

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source_span

Here we directly relate patterns of excitatory synaptic connectivity to visual response properties of neighbouring layer&#x2009;2/3 pyramidal neurons in mouse visual cortex at different postnatal ages, using two-photon calcium imaging in vivo and multiple whole-cell recordings in vitro.

evidence_refs

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evidence_summary

Sensory processing occurs in neocortical microcircuits in which synaptic connectivity is highly structured and excitatory neurons form subnetworks that process related sensory information. However, the developmental mechanisms underlying the formation of functionally organized connectivity in cortical microcircuits remain unknown. Here we directly relate patterns of excitatory synaptic connectivity to visual response properties of neighbouring layer&#x2009;2/3 pyramidal neurons in mouse visual c...

Here we directly relate patterns of excitatory synaptic connectivity to visual…

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Replication

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