Version history

{
  "scope": "mouse S1BF–POm–S2 brain slice (flavoprotein autofluorescence imaging)",
  "claim_text": "In mouse brain slices, layer-5B activation of S1 drives secondary somatosensory cortex via POm, with the transthalamic pathway abolished by thalamic inactivation.",
  "raw_fields": {
    "n": 9,
    "doi": "10.1038/nn.2449",
    "claim": "In mouse brain slices, layer-5B activation of S1 drives secondary somatosensory cortex via POm, with the transthalamic pathway abolished by thalamic inactivation.",
    "cite_key": "Theyel2009",
    "evidence": "Optical (flavoprotein autofluorescence) imaging plus pharmacological thalamic silencing during S1 layer-5B stimulation in mouse slices.",
    "effect_size": "89.8 ± 4.5% reduction of S2 ΔF/F upon thalamic silencing (n=9)",
    "text_access": "fulltext",
    "study_system": "mouse S1BF–POm–S2 brain slice (flavoprotein autofluorescence imaging)",
    "source_cluster_id": "cluster_05",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "The maximal secondary somatosensory cortex ΔF/F values decreased by 89.8 +/− 4.5% during runs with maximal thalamic inactivation (n = 9, p = 0.0007, paired t-test).",
    "replication_evidence_dois": [
      "10.1152/jn.00429.2011",
      "10.7554/elife.44158"
    ],
    "effect_size_source_sentence": "The maximal secondary somatosensory cortex ΔF/F values decreased by 89.8 +/− 4.5% during runs with maximal thalamic inactivation (n = 9, p = 0.0007, paired t-test)."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "effect_size": "89.8 ± 4.5% reduction of S2 ΔF/F upon thalamic silencing (n=9)",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-0d8e30351382"
  ],
  "source_span": "The maximal secondary somatosensory cortex ΔF/F values decreased by 89.8 +/− 4.5% during runs with maximal thalamic inactivation (n = 9, p = 0.0007, paired t-test).",
  "study_system": "mouse S1BF–POm–S2 brain slice (flavoprotein autofluorescence imaging)",
  "evidence_refs": [
    {
      "ref": "paper:paper-0d8e30351382"
    }
  ],
  "section_title": "Thalamic Feedback: Closing the Loop",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Optical (flavoprotein autofluorescence) imaging plus pharmacological thalamic silencing during S1 layer-5B stimulation in mouse slices.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}