Details
- scope
- mouse S1BF–POm–S2 brain slice (flavoprotein autofluorescence imaging)
- claim_text
- In mouse brain slices, layer-5B activation of S1 drives secondary somatosensory cortex via POm, with the transthalamic pathway abolished by thalamic inactivation.
- section_id
- section_06
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json
- effect_size
- 89.8 ± 4.5% reduction of S2 ΔF/F upon thalamic silencing (n=9)
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-06
- source_kind
- review_finding
- source_path
- evidence/section_06_evidence_package.json
- source_span
- The maximal secondary somatosensory cortex ΔF/F values decreased by 89.8 +/− 4.5% during runs with maximal thalamic inactivation (n = 9, p = 0.0007, paired t-test).
- study_system
- mouse S1BF–POm–S2 brain slice (flavoprotein autofluorescence imaging)
- section_title
- Thalamic Feedback: Closing the Loop
- evidence_summary
- Optical (flavoprotein autofluorescence) imaging plus pharmacological thalamic silencing during S1 layer-5B stimulation in mouse slices.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-06
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 9, "doi": "10.1038/nn.2449", "claim": "In mouse brain slices, layer-5B activation of S1 drives secondary somatosensory cortex via POm, with the transthalamic pathway abolished by thalamic inactivation.", "cite_key": "Theyel2009", "evidence": "Optical (flavoprotein autofluorescence) imaging plus pharmacological thalamic silencing during S1 layer-5B stimulation in mouse slices.", "effect_size": "89.8 ± 4.5% reduction of S2 ΔF/F upon thalamic silencing (n=9)", "text_access": "fulltext", "study_system": "mouse S1BF–POm–S2 brain slice (flavoprotein autofluorescence imaging)", "source_cluster_id": "cluster_05", "replication_status": "independently_replicated", "claim_source_sentence": "The maximal secondary somatosensory cortex ΔF/F values decreased by 89.8 +/− 4.5% during runs with maximal thalamic inactivation (n = 9, p = 0.0007, paired t-test).", "replication_evidence_dois": [ "10.1152/jn.00429.2011", "10.7554/elife.44158" ], "effect_size_source_sentence": "The maximal secondary somatosensory cortex ΔF/F values decreased by 89.8 +/− 4.5% during runs with maximal thalamic inactivation (n = 9, p = 0.0007, paired t-test)." }- source_refs
[ "paper:paper-0d8e30351382" ]
- evidence_refs
[ { "ref": "paper:paper-0d8e30351382" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }