- claim_text
Synaptically localized Kv3 channels at fast-spiking cell terminals keep action potentials brief, limiting Ca2+ influx and release probability, thereby influencing synaptic depression at synapses designed for sustained high-frequency transmission.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.0722-05.2005",
"claim": "Synaptically localized Kv3 channels at fast-spiking cell terminals keep action potentials brief, limiting Ca2+ influx and release probability, thereby influencing synaptic depression at synapses designed for sustained high-frequency transmission.",
"evidence": "In Kv3.1/Kv3.2 double knockout mice, TEA effects on GABA release were absent, spike-evoked GABA release was larger, and paired-pulse ratio was lower than wild-type.",
"effect_size": "spike-evoked GABA release enhanced ~2-fold by 1.0 mM TEA in WT; effect absent in Kv3.1/Kv3.2 DKO",
"text_access": "abstract_only",
"study_system": "mouse neocortex layer II/III, Kv3.1/Kv3.2 double knockout",
"replication_status": "independently_replicated",
"claim_source_sentence": "We propose that at FS cell terminals synaptically localized Kv3 channels keep APs brief, limiting Ca2+ influx and hence release probability, thereby influencing synaptic depression at a synapse designed for sustained high-frequency synaptic transmission.",
"replication_evidence_dois": [
"10.1523/jneurosci.4208-13.2014"
],
"effect_size_source_sentence": "Spike-evoked GABA release by FS cells was enhanced nearly twofold by 1.0 mM TEA, with a decrease in the paired pulse ratio, effects not reproduced by blockade of the non-Kv3 subfamily K+ channels."
}- source_refs
[
"paper:paper-20a89635af94"
]
- source_span
We propose that at FS cell terminals synaptically localized Kv3 channels keep APs brief, limiting Ca2+ influx and hence release probability, thereby influencing synaptic depression at a synapse designed for sustained high-frequency synaptic transmission.
- evidence_refs
[
{
"ref": "paper:paper-20a89635af94"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}