Version history

{
  "scope": "mouse neocortex layer II/III, Kv3.1/Kv3.2 double knockout",
  "claim_text": "Synaptically localized Kv3 channels at fast-spiking cell terminals keep action potentials brief, limiting Ca2+ influx and release probability, thereby influencing synaptic depression at synapses designed for sustained high-frequency transmission.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1523/jneurosci.0722-05.2005",
    "claim": "Synaptically localized Kv3 channels at fast-spiking cell terminals keep action potentials brief, limiting Ca2+ influx and release probability, thereby influencing synaptic depression at synapses designed for sustained high-frequency transmission.",
    "evidence": "In Kv3.1/Kv3.2 double knockout mice, TEA effects on GABA release were absent, spike-evoked GABA release was larger, and paired-pulse ratio was lower than wild-type.",
    "effect_size": "spike-evoked GABA release enhanced ~2-fold by 1.0 mM TEA in WT; effect absent in Kv3.1/Kv3.2 DKO",
    "text_access": "abstract_only",
    "study_system": "mouse neocortex layer II/III, Kv3.1/Kv3.2 double knockout",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We propose that at FS cell terminals synaptically localized Kv3 channels keep APs brief, limiting Ca2+ influx and hence release probability, thereby influencing synaptic depression at a synapse designed for sustained high-frequency synaptic transmission.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.4208-13.2014"
    ],
    "effect_size_source_sentence": "Spike-evoked GABA release by FS cells was enhanced nearly twofold by 1.0 mM TEA, with a decrease in the paired pulse ratio, effects not reproduced by blockade of the non-Kv3 subfamily K+ channels."
  },
  "section_id": "section_05_evidence_package",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "effect_size": "spike-evoked GABA release enhanced ~2-fold by 1.0 mM TEA in WT; effect absent in Kv3.1/Kv3.2 DKO",
  "review_repo": "ComputationalReviewPV",
  "section_ref": "wiki_page:computationalreviewpv-05",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-20a89635af94"
  ],
  "source_span": "We propose that at FS cell terminals synaptically localized Kv3 channels keep APs brief, limiting Ca2+ influx and hence release probability, thereby influencing synaptic depression at a synapse designed for sustained high-frequency synaptic transmission.",
  "study_system": "mouse neocortex layer II/III, Kv3.1/Kv3.2 double knockout",
  "evidence_refs": [
    {
      "ref": "paper:paper-20a89635af94"
    }
  ],
  "section_title": "Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
  },
  "evidence_summary": "In Kv3.1/Kv3.2 double knockout mice, TEA effects on GABA release were absent, spike-evoked GABA release was larger, and paired-pulse ratio was lower than wild-type.",
  "review_bundle_ref": "analysis_bundle:ab-e6261c8263e7",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-e6261c8263e7",
  "source_artifact_ref": "wiki_page:computationalreviewpv-05",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_05_evidence_package.json",
  "commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}