Version history

{
  "scope": "Mouse barrel cortex L2/3 pyramidal neurons, spike-timing pairing via L4 input (slice)",
  "claim_text": "Whisker deprivation in mice increases the probability of inducing spike-timing-dependent LTP at L4→L2/3 inputs in barrel cortex (from 33% to 53%) while decreasing the incidence of LTD (49% to 9%) for the same pairing protocol.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1002/cne.22583",
    "claim": "Whisker deprivation in mice increases the probability of inducing spike-timing-dependent LTP at L4→L2/3 inputs in barrel cortex (from 33% to 53%) while decreasing the incidence of LTD (49% to 9%) for the same pairing protocol.",
    "cite_key": "Hardingham2011",
    "evidence": "Reconstructed-neuron analysis showed undeprived LTP-capable cells had broader horizontal dendrites; deprivation removed this anatomical association and increased basal/apical spine density without altering dendritic structure.",
    "effect_size": "LTP incidence 33% → 53%; LTD incidence 49% → 9% after 7 d whisker deprivation",
    "text_access": "abstract_only",
    "study_system": "Mouse barrel cortex L2/3 pyramidal neurons, spike-timing pairing via L4 input (slice)",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "The probability of inducing LTP increased from 33% in cortex of undeprived mice to 53% following 7 days of whisker deprivation, and the incidence of LTD with the same protocol decreased from 49% to 9%.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "The probability of inducing LTP increased from 33% in cortex of undeprived mice to 53% following 7 days of whisker deprivation, and the incidence of LTD with the same protocol decreased from 49% to 9%."
  },
  "section_id": "section_12",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json",
  "effect_size": "LTP incidence 33% → 53%; LTD incidence 49% → 9% after 7 d whisker deprivation",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-12-plasticity",
  "source_kind": "review_finding",
  "source_path": "evidence/section_12_evidence_package.json",
  "source_refs": [
    "paper:paper-f74ca76e5851"
  ],
  "source_span": "The probability of inducing LTP increased from 33% in cortex of undeprived mice to 53% following 7 days of whisker deprivation, and the incidence of LTD with the same protocol decreased from 49% to 9%.",
  "study_system": "Mouse barrel cortex L2/3 pyramidal neurons, spike-timing pairing via L4 input (slice)",
  "evidence_refs": [
    {
      "ref": "paper:paper-f74ca76e5851"
    }
  ],
  "section_title": "12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Reconstructed-neuron analysis showed undeprived LTP-capable cells had broader horizontal dendrites; deprivation removed this anatomical association and increased basal/apical spine density without altering dendritic structure.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-12-plasticity",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}