Whisker deprivation in mice increases the probability of inducing spike-timing-…

Details

scope: Mouse barrel cortex L2/3 pyramidal neurons, spike-timing pairing via L4 input (slice)
claim_text: Whisker deprivation in mice increases the probability of inducing spike-timing-dependent LTP at L4→L2/3 inputs in barrel cortex (from 33% to 53%) while decreasing the incidence of LTD (49% to 9%) for the same pairing protocol.
section_id: section_12
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
effect_size: LTP incidence 33% → 53%; LTD incidence 49% → 9% after 7 d whisker deprivation
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-12-plasticity
source_kind: review_finding
source_path: evidence/section_12_evidence_package.json
source_span: The probability of inducing LTP increased from 33% in cortex of undeprived mice to 53% following 7 days of whisker deprivation, and the incidence of LTD with the same protocol decreased from 49% to 9%.
study_system: Mouse barrel cortex L2/3 pyramidal neurons, spike-timing pairing via L4 input (slice)
section_title: 12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning
evidence_summary: Reconstructed-neuron analysis showed undeprived LTP-capable cells had broader horizontal dendrites; deprivation removed this anatomical association and increased basal/apical spine density without altering dendritic structure.
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-12-plasticity
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1002/cne.22583",
  "claim": "Whisker deprivation in mice increases the probability of inducing spike-timing-dependent LTP at L4→L2/3 inputs in barrel cortex (from 33% to 53%) while decreasing the incidence of LTD (49% to 9%) for the same pairing protocol.",
  "cite_key": "Hardingham2011",
  "evidence": "Reconstructed-neuron analysis showed undeprived LTP-capable cells had broader horizontal dendrites; deprivation removed this anatomical association and increased basal/apical spine density without altering dendritic structure.",
  "effect_size": "LTP incidence 33% → 53%; LTD incidence 49% → 9% after 7 d whisker deprivation",
  "text_access": "abstract_only",
  "study_system": "Mouse barrel cortex L2/3 pyramidal neurons, spike-timing pairing via L4 input (slice)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "The probability of inducing LTP increased from 33% in cortex of undeprived mice to 53% following 7 days of whisker deprivation, and the incidence of LTD with the same protocol decreased from 49% to 9%.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "The probability of inducing LTP increased from 33% in cortex of undeprived mice to 53% following 7 days of whisker deprivation, and the incidence of LTD with the same protocol decreased from 49% to 9%."
}

source_refs

[
  "paper:paper-f74ca76e5851"
]

evidence_refs

[
  {
    "ref": "paper:paper-f74ca76e5851"
  }
]

source_policy

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Whisker deprivation in mice increases the probability of inducing spike-timing-…

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