Version history

{
  "scope": "mouse cortex, conditional Prox1 KO in CGE lineage",
  "claim_text": "The transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors; loss of Prox1 impairs their integration into superficial cortical layers and differentially regulates the postnatal maturation of RELN+, calbindin2/VIP+, and VIP+ subtypes, working in tandem with activity-dependent extrinsic pathways.",
  "raw_fields": {
    "n": null,
    "doi": "10.1523/jneurosci.1164-15.2015",
    "claim": "The transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors; loss of Prox1 impairs their integration into superficial cortical layers and differentially regulates the postnatal maturation of RELN+, calbindin2/VIP+, and VIP+ subtypes, working in tandem with activity-dependent extrinsic pathways.",
    "title": null,
    "cite_key": "Miyoshi2015",
    "evidence": "Abstract: conditional Prox1 deletion in CGE-derived interneurons of mouse cortex; combined with morphological, immunohistochemical and electrophysiological characterization across postnatal stages.",
    "effect_size": "Prox1 first identified transcription factor required for CGE-derived interneuron acquisition of subtype-specific properties; differential subtype effects on RELN+, Calb2/VIP+, VIP+",
    "text_access": "abstract_only",
    "study_system": "mouse cortex, conditional Prox1 KO in CGE lineage",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "replicated",
    "_source_cluster_index": 14,
    "claim_source_sentence": "Here, we report that in mice expression of the transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors and that loss of Prox1 impairs the integration of these cells into superficial layers.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.1021-21.2021",
      "10.1371/journal.pone.0077339"
    ],
    "effect_size_source_sentence": "Moreover, Prox1 differentially regulates the postnatal maturation of each specific subtype originating from the CGE (RELN, Calb2/VIP, and VIP)."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": "Prox1 first identified transcription factor required for CGE-derived interneuron acquisition of subtype-specific properties; differential subtype effects on RELN+, Calb2/VIP+, VIP+",
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-723f84ba97fd"
  ],
  "source_span": "Here, we report that in mice expression of the transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors and that loss of Prox1 impairs the integration of these cells into superficial layers.",
  "study_system": "mouse cortex, conditional Prox1 KO in CGE lineage",
  "evidence_refs": [
    {
      "ref": "paper:paper-723f84ba97fd"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Abstract: conditional Prox1 deletion in CGE-derived interneurons of mouse cortex; combined with morphological, immunohistochemical and electrophysiological characterization across postnatal stages.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "replicated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}