The transcription factor Prox1 is selectively maintained in postmitotic CGE-der…

The transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors; loss of Prox1 impairs their integration into superficial cortical layers and differentially regulates the postnatal maturation of RELN+, calbindin2/VIP+, and VIP+ subtypes, working in tandem with activity-dependent extrinsic pathways.

{
  "n": null,
  "doi": "10.1523/jneurosci.1164-15.2015",
  "claim": "The transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors; loss of Prox1 impairs their integration into superficial cortical layers and differentially regulates the postnatal maturation of RELN+, calbindin2/VIP+, and VIP+ subtypes, working in tandem with activity-dependent extrinsic pathways.",
  "title": null,
  "cite_key": "Miyoshi2015",
  "evidence": "Abstract: conditional Prox1 deletion in CGE-derived interneurons of mouse cortex; combined with morphological, immunohistochemical and electrophysiological characterization across postnatal stages.",
  "effect_size": "Prox1 first identified transcription factor required for CGE-derived interneuron acquisition of subtype-specific properties; differential subtype effects on RELN+, Calb2/VIP+, VIP+",
  "text_access": "abstract_only",
  "study_system": "mouse cortex, conditional Prox1 KO in CGE lineage",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replicated",
  "_source_cluster_index": 14,
  "claim_source_sentence": "Here, we report that in mice expression of the transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors and that loss of Prox1 impairs the integration of these cells into superficial layers.",
  "replication_evidence_dois": [
    "10.1523/jneurosci.1021-21.2021",
    "10.1371/journal.pone.0077339"
  ],
  "effect_size_source_sentence": "Moreover, Prox1 differentially regulates the postnatal maturation of each specific subtype originating from the CGE (RELN, Calb2/VIP, and VIP)."
}

[
  "paper:paper-723f84ba97fd"
]

Here, we report that in mice expression of the transcription factor Prox1 is selectively maintained in postmitotic CGE-derived cortical interneuron precursors and that loss of Prox1 impairs the integration of these cells into superficial layers.

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