Cross-modal sensory selection in mice depends on PFC interactions with the visu…

Details

scope: mouse PFC–visTRN–LGN (cross-modal divided-attention task)
claim_text: Cross-modal sensory selection in mice depends on PFC interactions with the visual thalamic reticular nucleus (visTRN), whose feedforward inhibition dynamically controls visual thalamic gain.
section_id: section_06
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json
effect_size: Performance on two modalities balanced; n=15 mice; visTRN photoinhibition produces modality-specific behavioral changes
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-06
source_kind: review_finding
source_path: evidence/section_06_evidence_package.json
source_span: Equivalent sensory thalamocortical manipulations showed that behaviour was causally dependent on PFC interactions with the sensory thalamus, not sensory cortex.
study_system: mouse PFC–visTRN–LGN (cross-modal divided-attention task)
section_title: Thalamic Feedback: Closing the Loop
evidence_summary: Optogenetic perturbations of PFC and visTRN with electrophysiology and intracellular chloride photometry during a cross-modal divided-attention task in mice.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-06
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 15,
  "doi": "10.1038/nature15398",
  "claim": "Cross-modal sensory selection in mice depends on PFC interactions with the visual thalamic reticular nucleus (visTRN), whose feedforward inhibition dynamically controls visual thalamic gain.",
  "cite_key": "Wimmer2015",
  "evidence": "Optogenetic perturbations of PFC and visTRN with electrophysiology and intracellular chloride photometry during a cross-modal divided-attention task in mice.",
  "effect_size": "Performance on two modalities balanced; n=15 mice; visTRN photoinhibition produces modality-specific behavioral changes",
  "text_access": "fulltext",
  "study_system": "mouse PFC–visTRN–LGN (cross-modal divided-attention task)",
  "source_cluster_id": "cluster_05",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Equivalent sensory thalamocortical manipulations showed that behaviour was causally dependent on PFC interactions with the sensory thalamus, not sensory cortex.",
  "replication_evidence_dois": [
    "10.1126/science.1223082",
    "10.1038/nature22073"
  ],
  "effect_size_source_sentence": "Performance on the two modalities was balanced (n = 15 mice, Fig."
}

source_refs

[
  "paper:paper-2a53381ce8a2"
]

evidence_refs

[
  {
    "ref": "paper:paper-2a53381ce8a2"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

Cross-modal sensory selection in mice depends on PFC interactions with the visu…

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