Version history

{
  "scope": "shortstop mouse vs YAC128 full-length mutant huntingtin mouse",
  "claim_text": "In the shortstop mouse, widespread N-terminal huntingtin inclusions occur without neuronal dysfunction or degeneration, indicating inclusions are not pathogenic in vivo and that excitotoxicity—not aggregation—mediates HD neurodegeneration.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1073/pnas.0503634102",
    "claim": "In the shortstop mouse, widespread N-terminal huntingtin inclusions occur without neuronal dysfunction or degeneration, indicating inclusions are not pathogenic in vivo and that excitotoxicity—not aggregation—mediates HD neurodegeneration.",
    "cite_key": "Slow2005",
    "evidence": "Comparison of shortstop (N-terminal huntingtin fragment, ~120Q) with full-length YAC128 mouse: striatal volume, neuronal counts, and excitotoxic susceptibility.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "shortstop mouse vs YAC128 full-length mutant huntingtin mouse",
    "source_cluster_id": "cluster_13",
    "replication_status": "contested",
    "claim_source_sentence": "These results indicate\nthat htt inclusions are not pathogenic in vivo .",
    "replication_evidence_dois": [
      "10.1073/pnas.0911503106",
      "10.1016/j.ymthe.2004.02.016"
    ],
    "effect_size_source_sentence": "Treatment of primary striatal neuronal cultures\nwith 500\n/H9262M NMDA resulted in 37% apoptotic death in YAC128\nmice compared with only 10% apoptotic death in WT (P /H110210.001)\nor shortstop (P /H110210.001; ANOVA,P /H110210.0001; n /H110053; Fig. 4 C and\nD)."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-14",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-087adaf4a7be"
  ],
  "source_span": "These results indicate that htt inclusions are not pathogenic in vivo .",
  "study_system": "shortstop mouse vs YAC128 full-length mutant huntingtin mouse",
  "evidence_refs": [
    {
      "ref": "paper:paper-087adaf4a7be"
    }
  ],
  "section_title": "Loop Dysfunction in Neurological and Psychiatric Disease",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Comparison of shortstop (N-terminal huntingtin fragment, ~120Q) with full-length YAC128 mouse: striatal volume, neuronal counts, and excitotoxic susceptibility.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "contested",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-14",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}