Details
- scope
- shortstop mouse vs YAC128 full-length mutant huntingtin mouse
- claim_text
- In the shortstop mouse, widespread N-terminal huntingtin inclusions occur without neuronal dysfunction or degeneration, indicating inclusions are not pathogenic in vivo and that excitotoxicity—not aggregation—mediates HD neurodegeneration.
- section_id
- section_14
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-14
- source_kind
- review_finding
- source_path
- evidence/section_14_evidence_package.json
- source_span
- These results indicate that htt inclusions are not pathogenic in vivo .
- study_system
- shortstop mouse vs YAC128 full-length mutant huntingtin mouse
- section_title
- Loop Dysfunction in Neurological and Psychiatric Disease
- evidence_summary
- Comparison of shortstop (N-terminal huntingtin fragment, ~120Q) with full-length YAC128 mouse: striatal volume, neuronal counts, and excitotoxic susceptibility.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- contested
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-14
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1073/pnas.0503634102", "claim": "In the shortstop mouse, widespread N-terminal huntingtin inclusions occur without neuronal dysfunction or degeneration, indicating inclusions are not pathogenic in vivo and that excitotoxicity—not aggregation—mediates HD neurodegeneration.", "cite_key": "Slow2005", "evidence": "Comparison of shortstop (N-terminal huntingtin fragment, ~120Q) with full-length YAC128 mouse: striatal volume, neuronal counts, and excitotoxic susceptibility.", "effect_size": null, "text_access": "fulltext", "study_system": "shortstop mouse vs YAC128 full-length mutant huntingtin mouse", "source_cluster_id": "cluster_13", "replication_status": "contested", "claim_source_sentence": "These results indicate\nthat htt inclusions are not pathogenic in vivo .", "replication_evidence_dois": [ "10.1073/pnas.0911503106", "10.1016/j.ymthe.2004.02.016" ], "effect_size_source_sentence": "Treatment of primary striatal neuronal cultures\nwith 500\n/H9262M NMDA resulted in 37% apoptotic death in YAC128\nmice compared with only 10% apoptotic death in WT (P /H110210.001)\nor shortstop (P /H110210.001; ANOVA,P /H110210.0001; n /H110053; Fig. 4 C and\nD)." }- source_refs
[ "paper:paper-087adaf4a7be" ]
- evidence_refs
[ { "ref": "paper:paper-087adaf4a7be" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }