Version history

{
  "scope": "mouse V1 L2/3 pyramidal neurons; functional EM (calcium imaging + ssEM)",
  "claim_text": "Anatomical reconstruction of mouse V1 L2/3 confirms that pyramidal cells with similar orientation tuning preferentially form synapses despite uniform axon–dendrite proximity, and these like-to-like synapses are larger.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1038/nature17192",
    "claim": "Anatomical reconstruction of mouse V1 L2/3 confirms that pyramidal cells with similar orientation tuning preferentially form synapses despite uniform axon–dendrite proximity, and these like-to-like synapses are larger.",
    "cite_key": "Lee2016",
    "evidence": "Combined in vivo two-photon calcium imaging and serial-section electron microscopy of an L2/3 volume in mouse V1; thousands of synapses scored against in vivo orientation preferences.",
    "effect_size": "Same-orientation pairs preferentially connected; like-to-like synapses larger on average",
    "text_access": "abstract_only",
    "study_system": "mouse V1 L2/3 pyramidal neurons; functional EM (calcium imaging + ssEM)",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "More specifically, we found that pyramidal neurons with similar orientation selectivity preferentially formed synapses with each other, despite the fact that axons and dendrites of all orientation selectivities pass near (<5 μm) each other with roughly equal probability.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.1038/nature09880",
      "10.1038/nature14182",
      "10.1038/s41586-025-08840-3"
    ],
    "effect_size_source_sentence": "Neurons with similar orientation tuning formed larger synapses, potentially enhancing the net effect of synaptic specificity."
  },
  "section_id": "section_05",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "effect_size": "Same-orientation pairs preferentially connected; like-to-like synapses larger on average",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "source_kind": "review_finding",
  "source_path": "evidence/section_05_evidence_package.json",
  "source_refs": [
    "paper:paper-d2a8c6775359"
  ],
  "source_span": "More specifically, we found that pyramidal neurons with similar orientation selectivity preferentially formed synapses with each other, despite the fact that axons and dendrites of all orientation selectivities pass near (<5 μm) each other with roughly equal probability.",
  "study_system": "mouse V1 L2/3 pyramidal neurons; functional EM (calcium imaging + ssEM)",
  "evidence_refs": [
    {
      "ref": "paper:paper-d2a8c6775359"
    }
  ],
  "section_title": "5. Horizontal long-range intracortical excitatory connections in mouse — patchy L2/3-L5 axons, similarity tuning, distance-decay",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Combined in vivo two-photon calcium imaging and serial-section electron microscopy of an L2/3 volume in mouse V1; thousands of synapses scored against in vivo orientation preferences.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-05-horizontal",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_05_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}