Anatomical reconstruction of mouse V1 L2/3 confirms that pyramidal cells with s…

{
  "n": 0,
  "doi": "10.1038/nature17192",
  "claim": "Anatomical reconstruction of mouse V1 L2/3 confirms that pyramidal cells with similar orientation tuning preferentially form synapses despite uniform axon–dendrite proximity, and these like-to-like synapses are larger.",
  "cite_key": "Lee2016",
  "evidence": "Combined in vivo two-photon calcium imaging and serial-section electron microscopy of an L2/3 volume in mouse V1; thousands of synapses scored against in vivo orientation preferences.",
  "effect_size": "Same-orientation pairs preferentially connected; like-to-like synapses larger on average",
  "text_access": "abstract_only",
  "study_system": "mouse V1 L2/3 pyramidal neurons; functional EM (calcium imaging + ssEM)",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "More specifically, we found that pyramidal neurons with similar orientation selectivity preferentially formed synapses with each other, despite the fact that axons and dendrites of all orientation selectivities pass near (<5 μm) each other with roughly equal probability.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature09880",
    "10.1038/nature14182",
    "10.1038/s41586-025-08840-3"
  ],
  "effect_size_source_sentence": "Neurons with similar orientation tuning formed larger synapses, potentially enhancing the net effect of synaptic specificity."
}

[
  "paper:paper-d2a8c6775359"
]

More specifically, we found that pyramidal neurons with similar orientation selectivity preferentially formed synapses with each other, despite the fact that axons and dendrites of all orientation selectivities pass near (<5 μm) each other with roughly equal probability.

[
  {
    "ref": "paper:paper-d2a8c6775359"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}