Version history

{
  "scope": "Whole-mouse-brain TissueCyte+2P imaging (MouseLight)",
  "claim_text": "The MouseLight platform integrates a high-speed two-photon microscope with serial vibratome sectioning and large-scale image computation to enable whole-mouse-brain reconstruction of axonal arbors as thin as ~100 nm — establishing the methodological baseline for single-neuron projectome work in mouse motor cortex.",
  "raw_fields": {
    "n": 0,
    "doi": "10.7554/elife.10566",
    "claim": "The MouseLight platform integrates a high-speed two-photon microscope with serial vibratome sectioning and large-scale image computation to enable whole-mouse-brain reconstruction of axonal arbors as thin as ~100 nm — establishing the methodological baseline for single-neuron projectome work in mouse motor cortex.",
    "cite_key": "Economo2016",
    "evidence": "Whole-mouse-brain 3D imaging at sub-diffraction axon resolution (100 nm); demonstrated reconstruction of multiple motor-cortex axonal arbors in one mouse.",
    "effect_size": "reconstruction of axons ≥100 nm diameter spanning entire mouse brain",
    "text_access": "fulltext",
    "study_system": "Whole-mouse-brain TissueCyte+2P imaging (MouseLight)",
    "argument_role": "supporting",
    "replication_status": "platform-paper",
    "claim_source_sentence": "We introduce a platform for high-resolution, three-dimensional fluorescence imaging of complete tissue volumes that enables the visualization and reconstruction of long-range axonal arbors. This platform relies on a high-speed two-photon microscope integrated with a tissue vibratome and a suite of computational tools for large-scale image data.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "axons with diameters as small as 100 nm arborize in target regions dispersed over many millimeters of tissue."
  },
  "section_id": "section_16",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "effect_size": "reconstruction of axons ≥100 nm diameter spanning entire mouse brain",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "source_kind": "review_finding",
  "source_path": "evidence/section_16_evidence_package.json",
  "source_refs": [
    "paper:b99d7c4a-9270-42c0-b083-2109f9c1eabf"
  ],
  "source_span": "We introduce a platform for high-resolution, three-dimensional fluorescence imaging of complete tissue volumes that enables the visualization and reconstruction of long-range axonal arbors. This platform relies on a high-speed two-photon microscope integrated with a tissue vibratome and a suite of computational tools for large-scale image data.",
  "study_system": "Whole-mouse-brain TissueCyte+2P imaging (MouseLight)",
  "evidence_refs": [
    {
      "ref": "paper:b99d7c4a-9270-42c0-b083-2109f9c1eabf"
    }
  ],
  "section_title": "16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Whole-mouse-brain 3D imaging at sub-diffraction axon resolution (100 nm); demonstrated reconstruction of multiple motor-cortex axonal arbors in one mouse.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "platform-paper",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}