Version history

{
  "scope": "mouse cortex and thalamus, Cre-driver lines",
  "claim_text": "Cre-driver-line tracing of ~1,000 cortical and thalamic projection experiments derived generalized anatomical rules for cortico-cortical, thalamocortical and corticothalamic projections and built a feedforward/feedback hierarchical model with cell-class-specific connections occupying a shallow hierarchy in the mouse cortex.",
  "raw_fields": {
    "n": 1000,
    "doi": "10.1038/s41586-019-1716-z",
    "claim": "Cre-driver-line tracing of ~1,000 cortical and thalamic projection experiments derived generalized anatomical rules for cortico-cortical, thalamocortical and corticothalamic projections and built a feedforward/feedback hierarchical model with cell-class-specific connections occupying a shallow hierarchy in the mouse cortex.",
    "cite_key": "Harris2019",
    "evidence": "~1,000 new viral tracer experiments across cortex and thalamus in Cre-driver mouse lines, integrated into the Allen Mouse Brain Connectivity Atlas.",
    "effect_size": "~1,000 tracer experiments; shallow hierarchy of cell-class-specific connections",
    "text_access": "abstract_only",
    "study_system": "mouse cortex and thalamus, Cre-driver lines",
    "argument_role": "supporting",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We used Cre driver lines (mice expressing Cre recombinase) to comprehensively and selectively label brain-wide connections by layer and class of projection neuron.",
    "source_provenance_status": "non_substring_match",
    "replication_evidence_dois": [
      "10.7554/eLife.97602",
      "10.1016/j.isci.2023.106316"
    ],
    "effect_size_source_sentence": "Our results show that cell-class-specific connections are organized in a shallow hierarchy within the mo"
  },
  "section_id": "section_07",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "effect_size": "~1,000 tracer experiments; shallow hierarchy of cell-class-specific connections",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "source_kind": "review_finding",
  "source_path": "evidence/section_07_evidence_package.json",
  "source_refs": [
    "paper:paper-259a50694faa"
  ],
  "source_span": "We used Cre driver lines (mice expressing Cre recombinase) to comprehensively and selectively label brain-wide connections by layer and class of projection neuron.",
  "study_system": "mouse cortex and thalamus, Cre-driver lines",
  "evidence_refs": [
    {
      "ref": "paper:paper-259a50694faa"
    }
  ],
  "section_title": "7. Cell-type-specific E→E motifs in mouse — IT vs PT vs CT pyramidal projection classes; L5 thick-tufted recurrence; Patch-seq and Allen mouse-cortex taxonomy intersections; transcriptomic-type-specific connectivity",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "~1,000 new viral tracer experiments across cortex and thalamus in Cre-driver mouse lines, integrated into the Allen Mouse Brain Connectivity Atlas.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_07_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}