In mouse M1, long-range monosynaptic inputs onto layer-5 deep output pyramidal…

In mouse M1, long-range monosynaptic inputs onto layer-5 deep output pyramidal neurons target both apical and basal dendritic compartments concurrently, with the two compartments innervated by spatially segregated neuronal subpopulations within the same upstream area (including individual cortical layers).

{
  "n": 0,
  "doi": "10.1093/cercor/bhab460",
  "claim": "In mouse M1, long-range monosynaptic inputs onto layer-5 deep output pyramidal neurons target both apical and basal dendritic compartments concurrently, with the two compartments innervated by spatially segregated neuronal subpopulations within the same upstream area (including individual cortical layers).",
  "cite_key": "Geng2022",
  "evidence": "Mouse M1 L5 deep output neurons targeted with Cre-dependent rabies virus tracing combined with layer-specific chemical retrograde tracing, channelrhodopsin-assisted optogenetic stimulation and whole-cell recording.",
  "effect_size": "Most upstream cortical and subcortical areas innervate both apical and basal dendrites; segregated subpopulations within source layer.",
  "text_access": "abstract_only",
  "study_system": "mouse M1, retrograde rabies tracing + layer-specific chemical tracing + optogenetic input mapping onto L5 deep output neurons",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "We revealed that most upstream areas innervate both dendritic compartments concurrently. These include the sensory cortices, higher motor cortices, sensory and motor thalamus, association cortices, as well as many subcortical nuclei. Furthermore, the dichotomous inputs arise mostly from spatially segregated neuronal subpopulations within an upstream nucleus, and even in the case of an individual cortical layer.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nature07709"
  ],
  "effect_size_source_sentence": null
}

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  "paper:paper-628d4113d368"
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We revealed that most upstream areas innervate both dendritic compartments concurrently. These include the sensory cortices, higher motor cortices, sensory and motor thalamus, association cortices, as well as many subcortical nuclei. Furthermore, the dichotomous inputs arise mostly from spatially segregated neuronal subpopulations within an upstream nucleus, and even in the case of an individual cortical layer.

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