The synaptic optoprobe AS-PaRac1 labels recently potentiated dendritic spines i…

The synaptic optoprobe AS-PaRac1 labels recently potentiated dendritic spines in mouse motor cortex and selectively shrinks them, and shrinkage of motor-task-potentiated spines disrupted only that motor skill — direct causal evidence that newly acquired motor learning in mouse cortex depends on a task-specific dense synaptic ensemble.

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  "doi": "10.1038/nature15257",
  "claim": "The synaptic optoprobe AS-PaRac1 labels recently potentiated dendritic spines in mouse motor cortex and selectively shrinks them, and shrinkage of motor-task-potentiated spines disrupted only that motor skill — direct causal evidence that newly acquired motor learning in mouse cortex depends on a task-specific dense synaptic ensemble.",
  "cite_key": "HayashiTakagi2015",
  "evidence": "AS-PaRac1 in vivo imaging + photoshrinkage; task-specificity of disruption.",
  "effect_size": "task-specific motor-learning disruption upon photoshrinkage of recently potentiated spines",
  "text_access": "abstract_only",
  "study_system": "Awake mouse motor cortex, in vivo 2P imaging + optogenetic Rac1",
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  "claim_source_sentence": "The acquired motor learning was disrupted by the optical shrinkage of the potentiated spines, whereas it was not affected by the identical manipulation of spines evoked by a distinct motor task in the same cortical region.",
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  "replication_evidence_dois": [],
  "effect_size_source_sentence": "The acquired motor learning was disrupted by the optical shrinkage of the potentiated spines"
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15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon

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