Version history

{
  "scope": "vip-interneurons",
  "claim_text": "COUP-TFI/COUP-TFII (Nr2f1/Nr2f2) are expressed in an arc-shaped MGE progenitor domain and control the spatial/temporal specification of SST+ vs PV+ MGE interneurons; their differential expression seeds layering and cell-fate divergence between the two major MGE subtypes.",
  "raw_fields": {
    "n": null,
    "doi": "10.1242/dev.150664",
    "year": "2017",
    "claim": "COUP-TFI/COUP-TFII (Nr2f1/Nr2f2) are expressed in an arc-shaped MGE progenitor domain and control the spatial/temporal specification of SST+ vs PV+ MGE interneurons; their differential expression seeds layering and cell-fate divergence between the two major MGE subtypes.",
    "title": null,
    "authors": "Hu JS, et al.",
    "journal": "Development (Cambridge, England)",
    "cite_key": "Hu2017",
    "effect_size": null,
    "text_access": "fulltext",
    "_source_cluster": "cluster_14_cge_lineage_context",
    "evidence_source": "fulltext",
    "cluster_relevance": "cge_lineage_context",
    "fulltext_available": true,
    "replication_status": null,
    "_source_cluster_index": 7,
    "claim_source_sentence": "Distinct cortical interneuron (CIN) subtypes have unique circuit functions; dysfunction in specific subtypes is implicated in neuropsychiatric disorders. Somatostatin- and parvalbumin-expressing (SST+ and PV+) interneurons are the two major subtypes generated by medial ganglionic eminence (MGE) progenitors. Spatial and temporal mechanisms governing their cell-fate specification and differential integration into cortical layers are largely unknown. We provide evidence that Coup-TF1 and Coup-TF2 (Nr2f1 and Nr2f2) transcription factor expression in an arc-shaped progenitor domain within the MGE promotes time-dependent survival of this neuroepithelium and the time-dependent specification of layer V SST+ CINs. Coup-TF1 and Coup-TF2 autonomously repress PV+ fate in MGE progenitors, in part through directly driving Sox6 expression. These results have identified, in mouse, a transcriptional pathway that controls SST-PV fate."
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-5fe32baac2c2"
  ],
  "source_span": "Distinct cortical interneuron (CIN) subtypes have unique circuit functions; dysfunction in specific subtypes is implicated in neuropsychiatric disorders. Somatostatin- and parvalbumin-expressing (SST+ and PV+) interneurons are the two major subtypes generated by medial ganglionic eminence (MGE) progenitors. Spatial and temporal mechanisms governing their cell-fate specification and differential integration into cort...",
  "study_system": null,
  "evidence_refs": [
    {
      "ref": "paper:paper-5fe32baac2c2"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": null,
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "unevaluated",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}