- claim_text
COUP-TFI/COUP-TFII (Nr2f1/Nr2f2) are expressed in an arc-shaped MGE progenitor domain and control the spatial/temporal specification of SST+ vs PV+ MGE interneurons; their differential expression seeds layering and cell-fate divergence between the two major MGE subtypes.
- raw_fields
{
"n": null,
"doi": "10.1242/dev.150664",
"year": "2017",
"claim": "COUP-TFI/COUP-TFII (Nr2f1/Nr2f2) are expressed in an arc-shaped MGE progenitor domain and control the spatial/temporal specification of SST+ vs PV+ MGE interneurons; their differential expression seeds layering and cell-fate divergence between the two major MGE subtypes.",
"title": null,
"authors": "Hu JS, et al.",
"journal": "Development (Cambridge, England)",
"cite_key": "Hu2017",
"effect_size": null,
"text_access": "fulltext",
"_source_cluster": "cluster_14_cge_lineage_context",
"evidence_source": "fulltext",
"cluster_relevance": "cge_lineage_context",
"fulltext_available": true,
"replication_status": null,
"_source_cluster_index": 7,
"claim_source_sentence": "Distinct cortical interneuron (CIN) subtypes have unique circuit functions; dysfunction in specific subtypes is implicated in neuropsychiatric disorders. Somatostatin- and parvalbumin-expressing (SST+ and PV+) interneurons are the two major subtypes generated by medial ganglionic eminence (MGE) progenitors. Spatial and temporal mechanisms governing their cell-fate specification and differential integration into cortical layers are largely unknown. We provide evidence that Coup-TF1 and Coup-TF2 (Nr2f1 and Nr2f2) transcription factor expression in an arc-shaped progenitor domain within the MGE promotes time-dependent survival of this neuroepithelium and the time-dependent specification of layer V SST+ CINs. Coup-TF1 and Coup-TF2 autonomously repress PV+ fate in MGE progenitors, in part through directly driving Sox6 expression. These results have identified, in mouse, a transcriptional pathway that controls SST-PV fate."
}- source_refs
[
"paper:paper-5fe32baac2c2"
]
- source_span
Distinct cortical interneuron (CIN) subtypes have unique circuit functions; dysfunction in specific subtypes is implicated in neuropsychiatric disorders. Somatostatin- and parvalbumin-expressing (SST+ and PV+) interneurons are the two major subtypes generated by medial ganglionic eminence (MGE) progenitors. Spatial and temporal mechanisms governing their cell-fate specification and differential integration into cort...
- evidence_refs
[
{
"ref": "paper:paper-5fe32baac2c2"
}
]- source_policy
{
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"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}