Version history

{
  "scope": "mouse VM/MD → PFC layer 1 (cell-type-specific optogenetics + 2P Ca²⁺ imaging)",
  "claim_text": "In mouse PFC, ventromedial thalamus targets NDNF+ interneurons in L1a and mediodorsal thalamus targets VIP+ interneurons in L1b, engaging distinct disinhibitory circuits and selectively gating dendritic Ca²⁺ spikes in L5 pyramidal-tract neurons.",
  "raw_fields": {
    "n": 7,
    "doi": "10.1016/j.neuron.2020.10.031",
    "claim": "In mouse PFC, ventromedial thalamus targets NDNF+ interneurons in L1a and mediodorsal thalamus targets VIP+ interneurons in L1b, engaging distinct disinhibitory circuits and selectively gating dendritic Ca²⁺ spikes in L5 pyramidal-tract neurons.",
    "cite_key": "Anastasiades2021",
    "evidence": "Tracing, optogenetics, two-photon Ca²⁺ imaging in mouse PFC slices and live tissue defining cell-type-specific L1 microcircuit targets.",
    "effect_size": "ains of VM inputs (5 pulses @ 10 Hz with a 473 nm LED) elicited r",
    "text_access": "fulltext",
    "study_system": "mouse VM/MD → PFC layer 1 (cell-type-specific optogenetics + 2P Ca²⁺ imaging)",
    "source_cluster_id": "cluster_05",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "We find thalamic inputs make distinct connections in L1, where VM engages NDNF+ cells in L1a, and MD drives VIP+ cells in L1b.",
    "replication_evidence_dois": [
      "10.1523/jneurosci.3231-12.2012",
      "10.1093/cercor/bhn259"
    ],
    "effect_size_source_sentence": "Trains of VM inputs (5 pulses @ 10 Hz with a 473 nm LED) elicited robust EPSCs at VIP− cells in L1a, which were much stronger than those at VIP+ cells in L1b (VIP− = −146 ± 41 pA, VIP+ = −6 ± 2 pA, p = 0.016; n = 7 pairs, 5 mice) ( Fig. 3A – B )."
  },
  "section_id": "section_06",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "effect_size": "ains of VM inputs (5 pulses @ 10 Hz with a 473 nm LED) elicited r",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-06",
  "source_kind": "review_finding",
  "source_path": "evidence/section_06_evidence_package.json",
  "source_refs": [
    "paper:paper-7227d2a3ed3e"
  ],
  "source_span": "We find thalamic inputs make distinct connections in L1, where VM engages NDNF+ cells in L1a, and MD drives VIP+ cells in L1b.",
  "study_system": "mouse VM/MD → PFC layer 1 (cell-type-specific optogenetics + 2P Ca²⁺ imaging)",
  "evidence_refs": [
    {
      "ref": "paper:paper-7227d2a3ed3e"
    }
  ],
  "section_title": "Thalamic Feedback: Closing the Loop",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "Tracing, optogenetics, two-photon Ca²⁺ imaging in mouse PFC slices and live tissue defining cell-type-specific L1 microcircuit targets.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-06",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}