Details
- scope
- mouse VM/MD → PFC layer 1 (cell-type-specific optogenetics + 2P Ca²⁺ imaging)
- section_id
- section_06
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json
- effect_size
- ains of VM inputs (5 pulses @ 10 Hz with a 473 nm LED) elicited r
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-06
- source_kind
- review_finding
- source_path
- evidence/section_06_evidence_package.json
- source_span
- We find thalamic inputs make distinct connections in L1, where VM engages NDNF+ cells in L1a, and MD drives VIP+ cells in L1b.
- study_system
- mouse VM/MD → PFC layer 1 (cell-type-specific optogenetics + 2P Ca²⁺ imaging)
- section_title
- Thalamic Feedback: Closing the Loop
- evidence_summary
- Tracing, optogenetics, two-photon Ca²⁺ imaging in mouse PFC slices and live tissue defining cell-type-specific L1 microcircuit targets.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-06
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_06_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
- claim_text
In mouse PFC, ventromedial thalamus targets NDNF+ interneurons in L1a and mediodorsal thalamus targets VIP+ interneurons in L1b, engaging distinct disinhibitory circuits and selectively gating dendritic Ca²⁺ spikes in L5 pyramidal-tract neurons.
- raw_fields
{ "n": 7, "doi": "10.1016/j.neuron.2020.10.031", "claim": "In mouse PFC, ventromedial thalamus targets NDNF+ interneurons in L1a and mediodorsal thalamus targets VIP+ interneurons in L1b, engaging distinct disinhibitory circuits and selectively gating dendritic Ca²⁺ spikes in L5 pyramidal-tract neurons.", "cite_key": "Anastasiades2021", "evidence": "Tracing, optogenetics, two-photon Ca²⁺ imaging in mouse PFC slices and live tissue defining cell-type-specific L1 microcircuit targets.", "effect_size": "ains of VM inputs (5 pulses @ 10 Hz with a 473 nm LED) elicited r", "text_access": "fulltext", "study_system": "mouse VM/MD → PFC layer 1 (cell-type-specific optogenetics + 2P Ca²⁺ imaging)", "source_cluster_id": "cluster_05", "replication_status": "independently_replicated", "claim_source_sentence": "We find thalamic inputs make distinct connections in L1, where VM engages NDNF+ cells in L1a, and MD drives VIP+ cells in L1b.", "replication_evidence_dois": [ "10.1523/jneurosci.3231-12.2012", "10.1093/cercor/bhn259" ], "effect_size_source_sentence": "Trains of VM inputs (5 pulses @ 10 Hz with a 473 nm LED) elicited robust EPSCs at VIP− cells in L1a, which were much stronger than those at VIP+ cells in L1b (VIP− = −146 ± 41 pA, VIP+ = −6 ± 2 pA, p = 0.016; n = 7 pairs, 5 mice) ( Fig. 3A – B )." }- source_refs
[ "paper:paper-7227d2a3ed3e" ]
- evidence_refs
[ { "ref": "paper:paper-7227d2a3ed3e" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }