Details

scope
Mouse neocortical pyramidal neurons (two-photon imaging, single-spine stimulation)
claim_text
In mouse neocortical pyramidal neurons, the amplitude of single-spine-evoked excitatory postsynaptic potentials is inversely correlated with spine neck length, supporting electrical compartmentalization by the spine neck.
section_id
section_12
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-12-plasticity
source_kind
review_finding
source_path
evidence/section_12_evidence_package.json
source_span
We find that excitatory postsynaptic potential amplitudes are inversely correlated with spine neck lengths.
study_system
Mouse neocortical pyramidal neurons (two-photon imaging, single-spine stimulation)
section_title
12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-12-plasticity
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
raw_fields
{
  "n": 0,
  "doi": "10.1073/pnas.1321869111",
  "claim": "In mouse neocortical pyramidal neurons, the amplitude of single-spine-evoked excitatory postsynaptic potentials is inversely correlated with spine neck length, supporting electrical compartmentalization by the spine neck.",
  "cite_key": "Araya2014",
  "evidence": "Two-photon calcium imaging with minimal synaptic stimulation in mouse cortical pyramidal neurons showed an inverse correlation between EPSP amplitude and spine neck length, implying that activity-dependent neck shortening would increase synaptic strength.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Mouse neocortical pyramidal neurons (two-photon imaging, single-spine stimulation)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We find that excitatory postsynaptic potential amplitudes are inversely correlated with spine neck lengths.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-838df624220f"
]
evidence_refs
[
  {
    "ref": "paper:paper-838df624220f"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}
evidence_summary
Two-photon calcium imaging with minimal synaptic stimulation in mouse cortical pyramidal neurons showed an inverse correlation between EPSP amplitude and spine neck length, implying that activity-dependent neck shortening would increase synaptic strength.

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