Version history

{
  "scope": "Mouse multi-lab Neuropixels reproducibility study; secondary visual areas / hippocampus / thalamus",
  "claim_text": "A 10-laboratory International Brain Laboratory replication study repeatedly targeted Neuropixels probes to the same brain locations (secondary visual areas, hippocampus, and thalamus) in mice performing a standardized decision-making task and developed RIGOR histological and electrophysiological quality-control criteria to enhance reproducibility.",
  "raw_fields": {
    "n": 121,
    "doi": "10.7554/elife.100840",
    "claim": "A 10-laboratory International Brain Laboratory replication study repeatedly targeted Neuropixels probes to the same brain locations (secondary visual areas, hippocampus, and thalamus) in mice performing a standardized decision-making task and developed RIGOR histological and electrophysiological quality-control criteria to enhance reproducibility.",
    "cite_key": "InternationalBrainLaboratory2025b",
    "evidence": "Empirical assessment that even with standardized hardware and task, electrode targeting and limited statistical power drive cross-lab variability; explicit QC criteria offered as mitigation.",
    "effect_size": "121 experimental replicates from 10 labs",
    "text_access": "fulltext",
    "study_system": "Mouse multi-lab Neuropixels reproducibility study; secondary visual areas / hippocampus / thalamus",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "This pipeline included stringent new histological and electrophysiological quality-control criteria (the ‘Recording Inclusion Guidelines for Optimizing Reproducibility’ [RIGOR]) that are applicable to datasets beyond our own.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "Experimenters in 10 laboratories repeatedly targeted Neuropixels probes to the same location (spanning secondary visual areas, hippocampus, and thalamus) in mice making decisions; this generated a total of 121 experimental replicates, a unique dataset for evaluating reproducibility of electrophysiology experiments."
  },
  "section_id": "section_16",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "effect_size": "121 experimental replicates from 10 labs",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "source_kind": "review_finding",
  "source_path": "evidence/section_16_evidence_package.json",
  "source_refs": [
    "paper:805df180-8279-474b-b134-8b931e75d832"
  ],
  "source_span": "This pipeline included stringent new histological and electrophysiological quality-control criteria (the ‘Recording Inclusion Guidelines for Optimizing Reproducibility’ [RIGOR]) that are applicable to datasets beyond our own.",
  "study_system": "Mouse multi-lab Neuropixels reproducibility study; secondary visual areas / hippocampus / thalamus",
  "evidence_refs": [
    {
      "ref": "paper:805df180-8279-474b-b134-8b931e75d832"
    }
  ],
  "section_title": "16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Empirical assessment that even with standardized hardware and task, electrode targeting and limited statistical power drive cross-lab variability; explicit QC criteria offered as mitigation.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}