Loss of PirB in mice increases spine density and stability on L5 pyramidal neur…

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scope: Mouse visual cortex L5 pyramidal neurons (PirB knockout vs WT)
claim_text: Loss of PirB in mice increases spine density and stability on L5 pyramidal neurons, augments LTP and reduces LTD, and produces larger, faster adult ocular-dominance plasticity, so PirB sets a structural threshold for cortical plasticity.
section_id: section_12
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
review_repo: ComputationalReviewRecurrence
section_ref: wiki_page:computationalreviewrecurrence-12-plasticity
source_kind: review_finding
source_path: evidence/section_12_evidence_package.json
source_span: In PirB(-/-) mice, spine density and stability are significantly greater than WT, associated with higher-frequency miniature synaptic currents, larger long-term potentiation, and deficient long-term depression.
study_system: Mouse visual cortex L5 pyramidal neurons (PirB knockout vs WT)
section_title: 12. Plasticity at E→E synapses in mouse — Hebbian, STDP, behavioural-time-scale plasticity; how plasticity shapes the recurrent matrix during learning
evidence_summary: PirB-/- mice showed higher spine density, larger mEPSC frequencies, enhanced LTP, deficient LTD, occluded MD-induced spine-density increase, and accelerated adult OD plasticity.
review_bundle_ref: analysis_bundle:ab-d9c479db9be9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d9c479db9be9
source_artifact_ref: wiki_page:computationalreviewrecurrence-12-plasticity
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_12_evidence_package.json
commit_sha: 79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1073/pnas.1321092110",
  "claim": "Loss of PirB in mice increases spine density and stability on L5 pyramidal neurons, augments LTP and reduces LTD, and produces larger, faster adult ocular-dominance plasticity, so PirB sets a structural threshold for cortical plasticity.",
  "cite_key": "Djurisic2013",
  "evidence": "PirB-/- mice showed higher spine density, larger mEPSC frequencies, enhanced LTP, deficient LTD, occluded MD-induced spine-density increase, and accelerated adult OD plasticity.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Mouse visual cortex L5 pyramidal neurons (PirB knockout vs WT)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "In PirB(-/-) mice, spine density and stability are significantly greater than WT, associated with higher-frequency miniature synaptic currents, larger long-term potentiation, and deficient long-term depression.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2021.07.030"
  ],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-025b3b812bb3"
]

evidence_refs

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  }
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source_policy

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Loss of PirB in mice increases spine density and stability on L5 pyramidal neur…

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