NARP is required for excitatory drive onto FS PV interneurons and is obligatory…

Details

scope: mouse, V1, NARP-/- transgenic
claim_text: NARP is required for excitatory drive onto FS PV interneurons and is obligatory for critical period plasticity
section_id: section_08_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
effect_size: decreased excitatory inputs; absent OD plasticity; recovery with enhanced inhibition
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-08
source_kind: review_finding
source_path: evidence/section_08_evidence_package.json
source_span: transgenic deletion of NARP decreases the number of excitatory synaptic inputs onto FS (PV) INs and reduces net excitatory synaptic drive
study_system: mouse, V1, NARP-/- transgenic
section_title: In Vivo Dynamics and Behavioural Correlates
evidence_summary: NARP-/- visual cortex is hyperexcitable and unable to express OD plasticity; enhancement of FS PV IN inhibitory output recovers plasticity
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-08
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.neuron.2013.05.016",
  "claim": "NARP is required for excitatory drive onto FS PV interneurons and is obligatory for critical period plasticity",
  "evidence": "NARP-/- visual cortex is hyperexcitable and unable to express OD plasticity; enhancement of FS PV IN inhibitory output recovers plasticity",
  "effect_size": "decreased excitatory inputs; absent OD plasticity; recovery with enhanced inhibition",
  "text_access": "abstract_only",
  "study_system": "mouse, V1, NARP-/- transgenic",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "transgenic deletion of NARP decreases the number of excitatory synaptic inputs onto FS (PV) INs and reduces net excitatory synaptic drive",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "enhancement of this output recovers the expression of experience-dependent synaptic plasticity"
}

source_refs

[
  "paper:paper-422871ce3ed0"
]

evidence_refs

[
  {
    "ref": "paper:paper-422871ce3ed0"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

NARP is required for excitatory drive onto FS PV interneurons and is obligatory…

Details

Replication

Discussion