An open, large-scale paired-recording dataset of mouse and human cortex shows t…

An open, large-scale paired-recording dataset of mouse and human cortex shows that the dynamics of excitatory synapses align with the postsynaptic cell subclass and that variability is the principal axis along which excitatory subclasses are organized; in the human cortex, E→E dynamics across L2 and L3 differ with cortical depth.

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  "n": 0,
  "doi": "10.1126/science.abj5861",
  "claim": "An open, large-scale paired-recording dataset of mouse and human cortex shows that the dynamics of excitatory synapses align with the postsynaptic cell subclass and that variability is the principal axis along which excitatory subclasses are organized; in the human cortex, E→E dynamics across L2 and L3 differ with cortical depth.",
  "cite_key": "Campagnola2022",
  "evidence": "Open Allen Institute synaptic physiology dataset of mouse and human cortical multi-patch recordings.",
  "effect_size": "Strength and variability identified as the two main axes of E synapse heterogeneity; subclasses divide by variability.",
  "text_access": "abstract_only",
  "study_system": "mouse and human neocortex; multi-patch paired-recording dataset (analysis of mouse data is in-scope)",
  "argument_role": "supporting",
  "replication_status": "single_study_landmark",
  "claim_source_sentence": "The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
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[
  "paper:paper-pm-40128391"
]

The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis account...

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    "ref": "paper:paper-pm-40128391"
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    "Local review repositories are read-only inputs.",
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  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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