Version history

{
  "scope": "mouse 3xTg-AD CA1 hippocampus I-S3 cells",
  "claim_text": "In young adult 3xTg-AD mice, hippocampal CA1 I-S3 cells (VIP+/CR+) preserve density and morphology but exhibit elongated action potentials and decreased firing rates, leading to reduced inhibition of CA1 SOM-INs/PV-INs and increased recruitment during spatial decision-making — early-stage VIP-IN circuit dysfunction precedes overt AD pathology.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.95412",
    "claim": "In young adult 3xTg-AD mice, hippocampal CA1 I-S3 cells (VIP+/CR+) preserve density and morphology but exhibit elongated action potentials and decreased firing rates, leading to reduced inhibition of CA1 SOM-INs/PV-INs and increased recruitment during spatial decision-making — early-stage VIP-IN circuit dysfunction precedes overt AD pathology.",
    "title": null,
    "cite_key": "Michaud2024",
    "evidence": "Patch-clamp + behavioral testing in 3xTg-AD vs nonTg littermates; n = 13–17 sections / 3 animals per genotype.",
    "effect_size": null,
    "figure_data": null,
    "text_access": "fulltext",
    "key_entities": [
      "VIP",
      "I-S3",
      "calretinin",
      "CA1",
      "3xTg-AD",
      "disinhibition",
      "action potential",
      "Alzheimer"
    ],
    "study_system": "mouse 3xTg-AD CA1 hippocampus I-S3 cells",
    "_source_cluster": "cluster_02_development_lineage",
    "replication_status": "single_study",
    "_source_cluster_index": 134,
    "claim_source_sentence": "Specifically, I-S3 cells displayed elongated action potentials and decreased firing rates, which was associated with a reduced inhibition of CA1 INs and their higher recruitment during spatial decision-making and object exploration tasks. ... we found that while the density and morphology of I-S3 cells remain unaffected, there were significant changes in their firing output.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_03",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewVIP",
  "section_ref": "wiki_page:computationalreviewvip-03-development",
  "source_kind": "review_finding",
  "source_path": "evidence/section_03_evidence_package.json",
  "source_refs": [
    "paper:paper-244a49e02ebb"
  ],
  "source_span": "Specifically, I-S3 cells displayed elongated action potentials and decreased firing rates, which was associated with a reduced inhibition of CA1 INs and their higher recruitment during spatial decision-making and object exploration tasks. ... we found that while the density and morphology of I-S3 cells remain unaffected, there were significant changes in their firing output.",
  "study_system": "mouse 3xTg-AD CA1 hippocampus I-S3 cells",
  "evidence_refs": [
    {
      "ref": "paper:paper-244a49e02ebb"
    }
  ],
  "section_title": "Developmental Origins and Postnatal Maturation",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
  },
  "evidence_summary": "Patch-clamp + behavioral testing in 3xTg-AD vs nonTg littermates; n = 13–17 sections / 3 animals per genotype.",
  "review_bundle_ref": "analysis_bundle:ab-2ce40c33e827",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-2ce40c33e827",
  "source_artifact_ref": "wiki_page:computationalreviewvip-03-development",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json",
  "commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}