In young adult 3xTg-AD mice, hippocampal CA1 I-S3 cells (VIP+/CR+) preserve den…

In young adult 3xTg-AD mice, hippocampal CA1 I-S3 cells (VIP+/CR+) preserve density and morphology but exhibit elongated action potentials and decreased firing rates, leading to reduced inhibition of CA1 SOM-INs/PV-INs and increased recruitment during spatial decision-making — early-stage VIP-IN circuit dysfunction precedes overt AD pathology.

{
  "n": null,
  "doi": "10.7554/elife.95412",
  "claim": "In young adult 3xTg-AD mice, hippocampal CA1 I-S3 cells (VIP+/CR+) preserve density and morphology but exhibit elongated action potentials and decreased firing rates, leading to reduced inhibition of CA1 SOM-INs/PV-INs and increased recruitment during spatial decision-making — early-stage VIP-IN circuit dysfunction precedes overt AD pathology.",
  "title": null,
  "cite_key": "Michaud2024",
  "evidence": "Patch-clamp + behavioral testing in 3xTg-AD vs nonTg littermates; n = 13–17 sections / 3 animals per genotype.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "fulltext",
  "key_entities": [
    "VIP",
    "I-S3",
    "calretinin",
    "CA1",
    "3xTg-AD",
    "disinhibition",
    "action potential",
    "Alzheimer"
  ],
  "study_system": "mouse 3xTg-AD CA1 hippocampus I-S3 cells",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 134,
  "claim_source_sentence": "Specifically, I-S3 cells displayed elongated action potentials and decreased firing rates, which was associated with a reduced inhibition of CA1 INs and their higher recruitment during spatial decision-making and object exploration tasks. ... we found that while the density and morphology of I-S3 cells remain unaffected, there were significant changes in their firing output.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-244a49e02ebb"
]

Specifically, I-S3 cells displayed elongated action potentials and decreased firing rates, which was associated with a reduced inhibition of CA1 INs and their higher recruitment during spatial decision-making and object exploration tasks. ... we found that while the density and morphology of I-S3 cells remain unaffected, there were significant changes in their firing output.

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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
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