Version history

{
  "scope": "Rat and rhesus macaque PET imaging; behavioral DREADD experiments",
  "claim_text": "Systemically administered CNO does not enter the brain; instead, in vivo conversion of CNO to clozapine is responsible for DREADD activation, with subthreshold systemic clozapine doses sufficient to drive DREADD-mediated behaviors.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1126/science.aan2475",
    "claim": "Systemically administered CNO does not enter the brain; instead, in vivo conversion of CNO to clozapine is responsible for DREADD activation, with subthreshold systemic clozapine doses sufficient to drive DREADD-mediated behaviors.",
    "cite_key": "Gomez2017",
    "evidence": "PET imaging of [11C]-clozapine binding to DREADD-expressing brain regions in rats and macaques; CNO does not occupy CNS DREADDs but converted clozapine does.",
    "effect_size": "11",
    "text_access": "fulltext",
    "study_system": "Rat and rhesus macaque PET imaging; behavioral DREADD experiments",
    "source_cluster_id": "cluster_10",
    "replication_status": "independently_replicated",
    "claim_source_sentence": "CNO does not enter the brain after systemic drug injections and shows low affinity for DREADDs. Clozapine, to which CNO rapidly converts in vivo, shows high DREADD affinity and potency.",
    "replication_evidence_dois": [
      "10.1016/j.neuron.2016.01.040"
    ],
    "effect_size_source_sentence": "PET imaging of [11C]-clozapine binding to DREADD-expressing brain regions in rats and macaques; CNO does not occupy CNS DREADDs but converted clozapine does."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": "11",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-faa5cef87aeb"
  ],
  "source_span": "CNO does not enter the brain after systemic drug injections and shows low affinity for DREADDs. Clozapine, to which CNO rapidly converts in vivo, shows high DREADD affinity and potency.",
  "study_system": "Rat and rhesus macaque PET imaging; behavioral DREADD experiments",
  "evidence_refs": [
    {
      "ref": "paper:paper-faa5cef87aeb"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "PET imaging of [11C]-clozapine binding to DREADD-expressing brain regions in rats and macaques; CNO does not occupy CNS DREADDs but converted clozapine does.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "independently_replicated",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}