Version history

{
  "scope": "Head-fixed mouse in virtual environment; LC-axon two-photon imaging + optogenetic stimulation in V1",
  "claim_text": "Locus coeruleus axons broadcast unsigned visuomotor prediction errors throughout mouse dorsal cortex and gate sensorimotor plasticity in V1.",
  "raw_fields": {
    "n": null,
    "doi": "10.7554/elife.85111",
    "claim": "Locus coeruleus axons broadcast unsigned visuomotor prediction errors throughout mouse dorsal cortex and gate sensorimotor plasticity in V1.",
    "cite_key": "Jordan2023",
    "evidence": "Two-photon imaging of LC axons across visual and motor cortex; optogenetic LC stimulation drove stimulus-specific suppression equivalent to multi-day visuomotor learning.",
    "effect_size": "Minutes of LC stimulation recapitulated visuomotor learning normally taking days",
    "text_access": "fulltext",
    "study_system": "Head-fixed mouse in virtual environment; LC-axon two-photon imaging + optogenetic stimulation in V1",
    "argument_role": "supporting",
    "replication_status": "replication_unknown",
    "claim_source_sentence": "We first assessed whether locus coeruleus (LC) axons convey sensorimotor prediction errors to the cortex.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "This plasticity - induced by minutes of LC stimulation - recapitulated the effect of visuomotor learning on a scale that is normally observed during visuomotor development across days."
  },
  "section_id": "section_14",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_14_evidence_package.json",
  "effect_size": "Minutes of LC stimulation recapitulated visuomotor learning normally taking days",
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-14-predictive-coding",
  "source_kind": "review_finding",
  "source_path": "evidence/section_14_evidence_package.json",
  "source_refs": [
    "paper:paper-532287620633"
  ],
  "source_span": "We first assessed whether locus coeruleus (LC) axons convey sensorimotor prediction errors to the cortex.",
  "study_system": "Head-fixed mouse in virtual environment; LC-axon two-photon imaging + optogenetic stimulation in V1",
  "evidence_refs": [
    {
      "ref": "paper:paper-532287620633"
    }
  ],
  "section_title": "14. Predictive-coding and dynamical-systems accounts — the role of recurrent excitatory feedback in error signalling, state estimation, and reservoir computing, evaluated against mouse data",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Two-photon imaging of LC axons across visual and motor cortex; optogenetic LC stimulation drove stimulus-specific suppression equivalent to multi-day visuomotor learning.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "replication_unknown",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-14-predictive-coding",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_14_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}