Details
- scope
- Head-fixed mouse in virtual environment; LC-axon two-photon imaging + optogenetic stimulation in V1
- claim_text
- Locus coeruleus axons broadcast unsigned visuomotor prediction errors throughout mouse dorsal cortex and gate sensorimotor plasticity in V1.
- section_id
- section_14
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_14_evidence_package.json
- effect_size
- Minutes of LC stimulation recapitulated visuomotor learning normally taking days
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-14-predictive-coding
- source_kind
- review_finding
- source_path
- evidence/section_14_evidence_package.json
- source_span
- We first assessed whether locus coeruleus (LC) axons convey sensorimotor prediction errors to the cortex.
- study_system
- Head-fixed mouse in virtual environment; LC-axon two-photon imaging + optogenetic stimulation in V1
- section_title
- 14. Predictive-coding and dynamical-systems accounts — the role of recurrent excitatory feedback in error signalling, state estimation, and reservoir computing, evaluated against mouse data
- evidence_summary
- Two-photon imaging of LC axons across visual and motor cortex; optogenetic LC stimulation drove stimulus-specific suppression equivalent to multi-day visuomotor learning.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-14-predictive-coding
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_14_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (4)
- raw_fields
{ "n": null, "doi": "10.7554/elife.85111", "claim": "Locus coeruleus axons broadcast unsigned visuomotor prediction errors throughout mouse dorsal cortex and gate sensorimotor plasticity in V1.", "cite_key": "Jordan2023", "evidence": "Two-photon imaging of LC axons across visual and motor cortex; optogenetic LC stimulation drove stimulus-specific suppression equivalent to multi-day visuomotor learning.", "effect_size": "Minutes of LC stimulation recapitulated visuomotor learning normally taking days", "text_access": "fulltext", "study_system": "Head-fixed mouse in virtual environment; LC-axon two-photon imaging + optogenetic stimulation in V1", "argument_role": "supporting", "replication_status": "replication_unknown", "claim_source_sentence": "We first assessed whether locus coeruleus (LC) axons convey sensorimotor prediction errors to the cortex.", "source_provenance_status": "ok", "replication_evidence_dois": [], "effect_size_source_sentence": "This plasticity - induced by minutes of LC stimulation - recapitulated the effect of visuomotor learning on a scale that is normally observed during visuomotor development across days." }- source_refs
[ "paper:paper-532287620633" ]
- evidence_refs
[ { "ref": "paper:paper-532287620633" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }