- claim_text
Two-photon optogenetic stimulation techniques — spiral scanning, temporal focusing, and three-dimensional computer-generated holography — drive hundreds of specifically targeted mouse-cortex neurons simultaneously with flexible reconfiguration of stimulation patterns, providing single-cell precision unavailable to one-photon optogenetics.
- raw_fields
{
"n": 0,
"doi": "10.1117/1.nph.13.1.010601",
"claim": "Two-photon optogenetic stimulation techniques — spiral scanning, temporal focusing, and three-dimensional computer-generated holography — drive hundreds of specifically targeted mouse-cortex neurons simultaneously with flexible reconfiguration of stimulation patterns, providing single-cell precision unavailable to one-photon optogenetics.",
"cite_key": "Hira2026",
"evidence": "Methods review of two-photon optogenetic toolkit underpinning all-optical interrogation of mouse-cortex circuits — central to cluster_14 emerging tools.",
"effect_size": null,
"text_access": "fulltext",
"study_system": "Two-photon optogenetic stimulation methods in mouse cortex (review)",
"argument_role": "supporting",
"replication_status": "single-study",
"claim_source_sentence": "Unlike conventional electrophysiological approaches or one-photon optogenetics, which inevitably activate many neurons surrounding the target, two-photon optogenetics can drive hundreds of specifically targeted neurons simultaneously, with stimulation patterns that can be flexibly and rapidly reconfigured.",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-3fa59c9a9842"
]
- source_span
Unlike conventional electrophysiological approaches or one-photon optogenetics, which inevitably activate many neurons surrounding the target, two-photon optogenetics can drive hundreds of specifically targeted neurons simultaneously, with stimulation patterns that can be flexibly and rapidly reconfigured.
- evidence_refs
[
{
"ref": "paper:paper-3fa59c9a9842"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}