Version history

{
  "scope": "Two-photon optogenetic stimulation methods in mouse cortex (review)",
  "claim_text": "Two-photon optogenetic stimulation techniques — spiral scanning, temporal focusing, and three-dimensional computer-generated holography — drive hundreds of specifically targeted mouse-cortex neurons simultaneously with flexible reconfiguration of stimulation patterns, providing single-cell precision unavailable to one-photon optogenetics.",
  "raw_fields": {
    "n": 0,
    "doi": "10.1117/1.nph.13.1.010601",
    "claim": "Two-photon optogenetic stimulation techniques — spiral scanning, temporal focusing, and three-dimensional computer-generated holography — drive hundreds of specifically targeted mouse-cortex neurons simultaneously with flexible reconfiguration of stimulation patterns, providing single-cell precision unavailable to one-photon optogenetics.",
    "cite_key": "Hira2026",
    "evidence": "Methods review of two-photon optogenetic toolkit underpinning all-optical interrogation of mouse-cortex circuits — central to cluster_14 emerging tools.",
    "effect_size": null,
    "text_access": "fulltext",
    "study_system": "Two-photon optogenetic stimulation methods in mouse cortex (review)",
    "argument_role": "supporting",
    "replication_status": "single-study",
    "claim_source_sentence": "Unlike conventional electrophysiological approaches or one-photon optogenetics, which inevitably activate many neurons surrounding the target, two-photon optogenetics can drive hundreds of specifically targeted neurons simultaneously, with stimulation patterns that can be flexibly and rapidly reconfigured.",
    "source_provenance_status": "ok",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": null
  },
  "section_id": "section_16",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "effect_size": null,
  "review_repo": "ComputationalReviewRecurrence",
  "section_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "source_kind": "review_finding",
  "source_path": "evidence/section_16_evidence_package.json",
  "source_refs": [
    "paper:paper-3fa59c9a9842"
  ],
  "source_span": "Unlike conventional electrophysiological approaches or one-photon optogenetics, which inevitably activate many neurons surrounding the target, two-photon optogenetics can drive hundreds of specifically targeted neurons simultaneously, with stimulation patterns that can be flexibly and rapidly reconfigured.",
  "study_system": "Two-photon optogenetic stimulation methods in mouse cortex (review)",
  "evidence_refs": [
    {
      "ref": "paper:paper-3fa59c9a9842"
    }
  ],
  "section_title": "16. Synthesis — which computational claims the mouse-cortex E→E empirical record actually supports, where the bottleneck observations are, and what an inhibition-free, single-species, basic-research analytic framing misses",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
  },
  "evidence_summary": "Methods review of two-photon optogenetic toolkit underpinning all-optical interrogation of mouse-cortex circuits — central to cluster_14 emerging tools.",
  "review_bundle_ref": "analysis_bundle:ab-d9c479db9be9",
  "replication_status": "single-study",
  "review_package_ref": "analysis_bundle:ab-d9c479db9be9",
  "source_artifact_ref": "wiki_page:computationalreviewrecurrence-16-synthesis",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_16_evidence_package.json",
  "commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}