Version history

{
  "scope": "C57BL/6J knock-in mouse driver and reporter lines, Allen Institute",
  "claim_text": "The Allen Institute TIGRE2.0 transgenic platform yields 23 new Cre/Flp driver lines (15 Cre, 8 Flp) and 26 new Cre-dependent reporter lines targeting cortical and subcortical cell populations, with markedly enhanced single-copy expression and simplified breeding compared to first-generation TIGRE.",
  "raw_fields": {
    "n": 23,
    "doi": "10.1016/j.cell.2018.06.035",
    "claim": "The Allen Institute TIGRE2.0 transgenic platform yields 23 new Cre/Flp driver lines (15 Cre, 8 Flp) and 26 new Cre-dependent reporter lines targeting cortical and subcortical cell populations, with markedly enhanced single-copy expression and simplified breeding compared to first-generation TIGRE.",
    "cite_key": "Daigle2018",
    "evidence": "In situ hybridization, IHC, and electrophysiological characterization across new lines; published Cre/Flp panel.",
    "effect_size": "23",
    "text_access": "fulltext",
    "study_system": "C57BL/6J knock-in mouse driver and reporter lines, Allen Institute",
    "source_cluster_id": "cluster_10",
    "replication_status": "single_study",
    "claim_source_sentence": "In this paper, we report a large and diverse set of new cell type-specific transgenic mouse lines, including 23 new driver lines (15 Cre and 8 Flp lines) and 26 new reporter lines.",
    "replication_evidence_dois": [],
    "effect_size_source_sentence": "In this paper, we report a large and diverse set of new cell type-specific transgenic mouse lines, including 23 new driver lines (15 Cre and 8 Flp lines) and 26 new reporter lines."
  },
  "section_id": "section_11",
  "source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "effect_size": "23",
  "review_repo": "ComputationalReviewLoops",
  "section_ref": "wiki_page:computationalreviewloops-11",
  "source_kind": "review_finding",
  "source_path": "evidence/section_11_evidence_package.json",
  "source_refs": [
    "paper:paper-c5041cb9303a"
  ],
  "source_span": "In this paper, we report a large and diverse set of new cell type-specific transgenic mouse lines, including 23 new driver lines (15 Cre and 8 Flp lines) and 26 new reporter lines.",
  "study_system": "C57BL/6J knock-in mouse driver and reporter lines, Allen Institute",
  "evidence_refs": [
    {
      "ref": "paper:paper-c5041cb9303a"
    }
  ],
  "section_title": "Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)",
  "source_policy": {
    "mode": "public_source_pointer_with_short_context",
    "notes": [
      "Local review repositories are read-only inputs.",
      "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
    ],
    "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
    "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
  },
  "evidence_summary": "In situ hybridization, IHC, and electrophysiological characterization across new lines; published Cre/Flp panel.",
  "review_bundle_ref": "analysis_bundle:ab-d49e54403ef9",
  "replication_status": "single_study",
  "review_package_ref": "analysis_bundle:ab-d49e54403ef9",
  "source_artifact_ref": "wiki_page:computationalreviewloops-11",
  "origin_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json",
  "commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "created_by": "persona-jerome-lecoq-gbo-neuroscience",
  "repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}