- claim_text
Locomotion-driven activation of VIP interneurons in mouse V1 is mediated by powerful nicotinic cholinergic input: local blockade of nicotinic but not glutamatergic transmission reduces VIP locomotion responses by >2/3; optogenetic VIP activation reproduces the locomotion-induced gain increase, and focal VIP damage blocks it.
- raw_fields
{
"n": 28,
"doi": "10.1016/j.cell.2014.01.050",
"claim": "Locomotion-driven activation of VIP interneurons in mouse V1 is mediated by powerful nicotinic cholinergic input: local blockade of nicotinic but not glutamatergic transmission reduces VIP locomotion responses by >2/3; optogenetic VIP activation reproduces the locomotion-induced gain increase, and focal VIP damage blocks it.",
"title": null,
"cite_key": "Fu2014",
"evidence": "In vivo two-photon Ca2+ imaging during locomotion + local pharmacological blockade; optogenetic activation/ablation; in vitro slice nicotinic recordings.",
"effect_size": ">2/3 reduction in VIP locomotion response with nicotinic block; cross-correlation >0.4 in 20/28 VIP vs 3/77 non-VIP neurons.",
"text_access": "fulltext",
"study_system": "mouse V1; in vivo + slice",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "independently_replicated",
"_source_cluster_index": 13,
"claim_source_sentence": "The local blockade of nicotinic cholinergic input, but not of glutamatergic input, reduced the response of VIP neurons to locomotion by more than two thirds, and measurements in vitro disclosed powerful nicotinic cholinergic input to VIP neurons.",
"replication_evidence_dois": [
"10.7554/elife.14985",
"10.1038/nn.4002",
"10.1523/jneurosci.19-13-05228.1999"
],
"effect_size_source_sentence": "While 20/28 imaged VIP neurons had a zero-time cross-correlation larger than 0.4, only 3/77 non-VIP neurons had a zero-time cross-correlation larger than 0.4 ( ), indicating that VIP neurons constitute the majority of the neurons responsive to locomotion in the absence of visual"
}- source_refs
[
"paper:paper-5cfe39bf225d"
]
- source_span
The local blockade of nicotinic cholinergic input, but not of glutamatergic input, reduced the response of VIP neurons to locomotion by more than two thirds, and measurements in vitro disclosed powerful nicotinic cholinergic input to VIP neurons.
- evidence_refs
[
{
"ref": "paper:paper-5cfe39bf225d"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}