Locomotion activates VIP-expressing interneurons in mouse V1 largely through ni…

{
  "n": null,
  "doi": "10.1016/j.cell.2014.01.050",
  "year": "2014",
  "claim": "Locomotion activates VIP-expressing interneurons in mouse V1 largely through nicotinic cholinergic inputs from the basal forebrain, and these VIP cells gate the locomotion-induced gain enhancement of visual responses.",
  "title": "A cortical circuit for gain control by behavioral state",
  "journal": "",
  "species": "mouse",
  "cite_key": "Fu2014",
  "evidence": "Two-photon imaging of VIP-Cre × GCaMP6 mice during running, pharmacology, optogenetic activation, and selective ablation of VIP cells.",
  "effect_size": "Optogenetic VIP activation in stationary mice mimicked locomotion gain; photolytic VIP ablation abolished locomotion-induced enhancement of V1 responses.",
  "text_access": "fulltext",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 0,
  "claim_source_sentence": "In vivo calcium imaging of behaving animals revealed that locomotion activates vasoactive intestinal peptide (VIP)-positive neurons in mouse V1 independent of visual stimulation and largely through nicotinic inputs from basal forebrain.",
  "replication_evidence_dois": [
    "10.7554/elife.14985",
    "10.1016/j.neuron.2018.03.037",
    "10.1016/j.celrep.2017.07.040"
  ],
  "effect_size_source_sentence": "Optogenetic activation of VIP neurons increased V1 visual responses in stationary awake mice, artificially mimicking the effect of locomotion, and photolytic damage of VIP neurons abolished the enhancement of V1 responses by locomotion."
}

[
  "paper:paper-5cfe39bf225d"
]

[
  {
    "ref": "paper:paper-5cfe39bf225d"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}